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논문 기본 정보

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학술저널
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대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제7권 제3호
발행연도
2011.1
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137 - 142 (6page)

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Background and Purpose The goal of this study was to estimate the efficacy and safety of the rivastigmine transdermal patch in patients with probable Alzheimer’s disease (AD) who cannot tolerate or do not respond to oral cholinesterase inhibitors (ChEIs). Methods A 24-week, prospective, open-label, single-arm, multicenter study was conducted from June 2009 to June 2010 in patients with probable AD. The enrolled patients had either a poor response or a decline in global function after treatment with oral ChEIs, or they were not able to tolerate treatment with oral ChEIs due to adverse events such as nausea or vomiting. A poor response was defined as a decrease of at least 2 points on the Korean version of the Mini-Mental State Examination (K-MMSE) within the previous 6 months (the decline in global function was determined by the investigator or caregiver). The efficacy of treatment was assessed using a follow-up Clinical Global Impression of Change (CGIC) assessment and K-MMSE conducted after 24 weeks, and safety was measured by the occurrence of adverse events and patient disposition. Results In total, 164 patients aged 74.7±7.52 years (mean±SD) and with 5.12±3.64 years of education were included. The study was completed by 70% of the patients (n=116), with 12.2%discontinuing due to adverse events. The most frequently reported adverse events (11%) were skin lesions, such as erythema or itching, followed by gastrointestinal problems (1.2%). Either an improvement or no decline in CGIC scores was reported for 82% of the patients. Conclusions The immediate switching of patients from an oral ChEI to the rivastigmine transdermal patch without a washout period was safe and well tolerated by the probable-AD patients in this study.
#cholinesterase inhibitors #rivastigmine transdermal patch #efficacy #safety #Alzheimer's disease.

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참고문헌 (22)

참고문헌 신청
Auriacombe S / 2002 / Efficacy and safety of rivastigmine in patients with Alzheimer’s disease who failed to bene-fit from treatment with donepezil / Curr Med Res Opin 18 : google schola Blesa R / 2007 / Caregiver pre-ference for rivastigmine patches versus capsules for the treatment of Alzheimer disease / Neurology 69 : 23 ~ 28 google schola Bullock R / 2002 / Switching cholinesterase inhibitor therapy in Alzheimer’s disease--donepezil to rivastigmine, is it worth it / Int J Ge-riatr Psychiatry 17 : 288 ~ 289 google schola Choi SH / 2001 / Estimating the validity of the Korean version of expanded clinical demen-tia rating (CDR) scale / J Korean Neurol Assoc 19 : 585 ~ 591 google schola Cummings J / 2007 / Pharmacokinetic rationale for the rivastigmine patch / Neurology 69 : 10 ~ 13 google schola

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