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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 69 - 76 (8page)
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Background and Purpose: Unstable carotid atherosclerotic plaques are characterized by cap rupture, leading to thromboembolism and stroke. Matrix metalloproteinases (MMPs) have been implicated in the progression of atherosclerosis and plaque rupture. The aim of this study was to assess the relationship between the expressions of MMP-2 and MMP-9 and carotid plaque instability.
Methods: Eighty atherosclerotic plaques were collected from 74 patients undergoing carotid endarterectomy. Clinical information was obtained from each patient, and plaque morphology was examined at the macroscopic and microscopic levels. The immunohistochemical expressions of MMPs were graded using semiquantitative scales.
Results: Macroscopic ulceration (84.6% versus 63.4%, p=0.042) and microscopic cap rupture (79.5% versus 51.2%, p=0.010) were more common in symptomatic than in asymptomatic patients.
Immunoreactivities of MMP-2 and MMP-9 were increased in 40 and 36 atheromatous plaques,respectively. Macroscopic ulceration was strongly correlated with the expressions of MMP-2(p<0.001) and MMP-9 (p=0.001). There were significant correlations between increased MMP2 expression and cap rupture (p=0.002), intraplaque hemorrhage (p=0.039), and a thin fibrous cap (p=0.002), and between increased MMP-9 expression and cap rupture (p=0.010) and a large lipid core (p=0.013).
Conclusions: Plaque rupture was significantly associated with the development of vascular events in carotid atherosclerotic disease. MMP-2 and MMP-9 are strongly correlated with plaque instability.
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참고문헌 (24)
참고문헌 신청
Aimes RT / 1995 / Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I colla
Barnett HJ / 1998 / Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collab
Bassiouny HS / 1989 / Critical carotid stenoses: morphologic and chemical similarity between symptomatic and asymptomatic plaques / J Vasc Surg 9 : 202 ~ 212
Carr S / 1996 / Atherosclerotic plaque rupture in symptomatic carotid artery stenosis / J Vasc Surg 23 : 755 ~ 765
European Carotid
Barnett HJ / 1998 / Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis. North American Symptomatic Carotid Endarterectomy Trial Collab
Bassiouny HS / 1989 / Critical carotid stenoses: morphologic and chemical similarity between symptomatic and asymptomatic plaques / J Vasc Surg 9 : 202 ~ 212
Carr S / 1996 / Atherosclerotic plaque rupture in symptomatic carotid artery stenosis / J Vasc Surg 23 : 755 ~ 765
European Carotid
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