지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 1 - 9 (9page)
이용수
초록· 키워드
오류제보하기
Cerebral amyloid angiopathy (CAA) is a disorder characterized by amyloid deposition in the walls of leptomeningeal and cortical arteries, arterioles, and less often capillaries and veins of the central nervous system. CAA occurs mostly as a sporadic condition in the elderly, its incidence associating with advancing age. All sporadic CAA cases are due to deposition of amyloid-β, originating from proteolytic cleavage of the Amyloid Precursor Protein. Hereditary forms of CAA are generally familial (and therefore rare in the general population), more severe and earlier in onset.
CAA-related lobar intracerebral hemorrhage is the most well-studied clinical condition associated with brain amyloid deposition. Despite ever increasing understanding of CAA pathogenesis and availability of reliable clinical and diagnostic tools, preventive and therapeutic options remain very limited. Further research efforts are required in order to identify biological targets for novel CAA treatment strategies. We present a systematic review of existing evidence regarding the epidemiology, genetics, pathogenesis, diagnosis and clinical management of CAA.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Burgermeister P / 2000 / Mechanisms of cerebrovascular amyloid deposition. Lessons from mouse models / Ann N Y Acad Sci 903 : 307 ~ 316
Busciglio J / 1993 / Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells / Proc Natl Acad Sci U S A 90 : 2082 ~ 2096
Chesebro B / 2005 / Anchorless prion protein results
Frangione B / 2001 / Familial cerebral amyloid angiopathy related to stroke and dementia / Amyloid 8 (Suppl 1) : 36 ~ 42
Ghiso J / 2006 / Genetic alterations of the BRI2 gene: familial British and Danish dementias / Brain Pathol 16 : 71 ~ 79
Busciglio J / 1993 / Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells / Proc Natl Acad Sci U S A 90 : 2082 ~ 2096
Chesebro B / 2005 / Anchorless prion protein results
Frangione B / 2001 / Familial cerebral amyloid angiopathy related to stroke and dementia / Amyloid 8 (Suppl 1) : 36 ~ 42
Ghiso J / 2006 / Genetic alterations of the BRI2 gene: familial British and Danish dementias / Brain Pathol 16 : 71 ~ 79
이 논문의 저자 정보
최근 본 자료
댓글(0)
0