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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 271 - 279 (9page)
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Previous studies to elucidate the etiology of cyclosporine(Cs)-induced gingival overgrowth in children have not completely excluded all factors that may cause differences among individuals. This study examined the effect of cyclosporine on the metabolism of type 1 collagen(CoL-I) in experimental models that controlled the effects of biological variations on individuals. Five 5-week-old male Sprague-Dawley rats were administered Cs by gastric feeding for 6 weeks. Gingival specimens were harvested from the mandibular posterior area before beginning Cs administration and at 2, 4, and 6 weeks thereafter. Gingival fibroblasts were cultured from all the 20 biopsies collected from the gingiva. Half of the fibroblasts collected prior to the Cs administration were designated as Control. The other half of the fibroblasts were treated with Cs in vitro and called in vitro test group(Tt). The fibroblasts collected 2, 4, and 6 weeks after the Cs administration were called in vivo test groups : T2, T4, T6, respectively. Immunofluorescence microscopy was used to detect CoL-I in all the fibroblasts. CoL-I was analyzed at both the gene and protein expression levels by real-time polymerase chain reaction and western blotting. Changes in CoL-I before and after Cs treatment were evaluated from the gingiva of each rat. There was no significant difference in gene expression of CoL-I in the control and test groups. CoL-I protein expression levels of fibroblasts increased in in vitro Cs treatment for each individual, and also increased in in vivo Cs treatment. In this study, the experimental method that control biological variations that can occur due to differences among individuals was useful. Subsequent studies on other factors besides CoL-I and in-depth studies in humans are needed.
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참고문헌 (28)
참고문헌 신청
Kahan BD / 1989 / Cyclosporine / N Engl J Med 321:1725~1738
Karpinia KA / 1996 / Factors affecting cyclosporine-induced gingival overgrowth in pediatric renal transplant recipients / Pediatr Dent 18:450~455
Bolzani G / 2000 / Cyclosporin A inhibits production and activity of matrix metalloproteinases by gingival fibroblasts / J Periodontal Res 35:51~58
Kataoka M / 2000 / Cyclosporin A decreases the degradation of type I collagen in rat gingival overgrowth / J Cell Physiol 182:351~358
Jiko M / 2002 / Evaluation of pharmacokinetic interaction between cyclosporin A and probucol in rats / Pharm Res 19:1362~1367
Karpinia KA / 1996 / Factors affecting cyclosporine-induced gingival overgrowth in pediatric renal transplant recipients / Pediatr Dent 18:450~455
Bolzani G / 2000 / Cyclosporin A inhibits production and activity of matrix metalloproteinases by gingival fibroblasts / J Periodontal Res 35:51~58
Kataoka M / 2000 / Cyclosporin A decreases the degradation of type I collagen in rat gingival overgrowth / J Cell Physiol 182:351~358
Jiko M / 2002 / Evaluation of pharmacokinetic interaction between cyclosporin A and probucol in rats / Pharm Res 19:1362~1367
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