지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제22권 제2호
- 발행연도
- 2012.1
- 수록면
- 129 - 137 (9page)
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초록· 키워드
오류제보하기
Asthma is a complex and heterogeneous disease, which is comprised of seperate phenotypes sharing common characteristics, such as airway inflammation, bronchial hyperresponsiveness and variable airflow limitation. Traditionally, asthma phenotypes have been described by combinations of clinical characteristics, according to the expert’s recommendation, but they are now focusing on the pathobiologic mechanisms often using exploratory statistical methods. Several phenotypes and endotypes have been suggested by biased or unbiased phenotyping approaches. However, more detailed studies are still needed. In the future, more integrated large-scaled consortium of cohorts,including clinical information, genetics, molecular biology, and experiments will promote to understand the pathobiologic mechanisms of asthma phenotypes for the personalized therapy.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Akhabir L / 2011 / Genome-wide association studies for discovery of genes involved in asthma / Respirology 16 : 396 ~ 406
Anderson GP / 2008 / Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease / Lancet 372 : 1107 ~ 1119
Bouzigon E / 2008 / Effect of 17q21 variants and smoking exposure in early-onset asthma / N Engl J Med 359 : 1985 ~ 1994
Busse W / 2001 / Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma / J Allergy Clin Immunol 108 : 184 ~ 190
European Community Respiratory Health Survey II Steering Committee / 2002 / The European Community Respiratory Health Survey II / Eur Respir J 20 : 1071 ~ 1079
Anderson GP / 2008 / Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease / Lancet 372 : 1107 ~ 1119
Bouzigon E / 2008 / Effect of 17q21 variants and smoking exposure in early-onset asthma / N Engl J Med 359 : 1985 ~ 1994
Busse W / 2001 / Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma / J Allergy Clin Immunol 108 : 184 ~ 190
European Community Respiratory Health Survey II Steering Committee / 2002 / The European Community Respiratory Health Survey II / Eur Respir J 20 : 1071 ~ 1079
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