지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제1권 제2호
- 발행연도
- 2013.1
- 수록면
- 168 - 171 (4page)
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초록· 키워드
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Vancomycin frequently induces hypersensitivity reactions including red man syndrome (RMS) and anaphylaxis. Lowering infusion rate with antihistamine premedication is usually effective to reduce RMS, however, desensitization should be considered for severe reactions not responding to usual measures. Here, we report a case of a patient with pyogenic spondylitis who had developed hypersensitivity reaction to vancomycin, got a full recovery with vancomycin desensitization. A 63-year-old man was transferred to our hospital for back pain, proved to pyogenic spondylitis. As methicillin-resistant Staphylococci aureus infection was suspected, vancomycin was administrated. But, he showed hypersensitivity reactions such as hypotension, dyspnea and severe flushing after vancomycin administration at previous hospital. Readministration of vancomycin at a lower infusion rate with premedication was tried. Three hours after vancomycin infusion, he developed fever, chills, rash and hypotension. Thrombocytopenia was occurred after administration of other antibiotics including cefazolin and teicoplanin. Vancomycin administration was attempted according to a rapid desensitization protocol. The infusion rate of vancomycin was increased to the standard rate. After the desensitization, he successfully completed the full course of treatment with vancomycin. Vancomycin desensitization could be the option for the vancomycin hypersensitivity when other antibiotics are not feasible.
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참고문헌 (17)
참고문헌 신청
Anne' S / 1994 / Vancomycin anaphylaxis and successful desensitization / Ann Allergy 73 : 402 ~ 404
Hassaballa H / 2000 / Vancomycin anaphylaxis in a patient with vancomycin-induced red man syndrome / Am J Ther 7 : 319 ~ 320
Kitazawa T / 2006 / Successful vancomycin desensitization with a combination of rapid and slow infusion methods / Intern Med 45 : 317 ~ 321
Korman TM / 1997 / Risk factors for adverse cutaneous reactions associated with intravenous vancomycin / J Antimicrob Chemother 39 : 371 ~ 381
Kupstaite R / 2010 / Severe vancomycin-induced anaphylactic reaction / Medicina (Kaunas) 46 : 30 ~ 33
Hassaballa H / 2000 / Vancomycin anaphylaxis in a patient with vancomycin-induced red man syndrome / Am J Ther 7 : 319 ~ 320
Kitazawa T / 2006 / Successful vancomycin desensitization with a combination of rapid and slow infusion methods / Intern Med 45 : 317 ~ 321
Korman TM / 1997 / Risk factors for adverse cutaneous reactions associated with intravenous vancomycin / J Antimicrob Chemother 39 : 371 ~ 381
Kupstaite R / 2010 / Severe vancomycin-induced anaphylactic reaction / Medicina (Kaunas) 46 : 30 ~ 33
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