지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아알레르기호흡기학회 Allergy Asthma & Respiratory Diseases Allergy Asthma & Respiratory Diseases 제3권 제6호
- 발행연도
- 2015.1
- 수록면
- 387 - 395 (9page)
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초록· 키워드
오류제보하기
Numerous disorders and etiologies may underlie increased eosinophil counts. Hypereosinophilia (HE) is defined as a peripheral blood eosinophil count greater than 1,500/mm3 and may be potentially harmful because of tissue damage. Hypereosinophilic syndrome (HES) also represents a heterogeneous disorder characterized by persistent HE with the evidence of organ dysfunction, clinical symptoms, or both caused by eosinophilia. The refining criteria and subclassification of HE and HES are currently being revised on cellular and molecular based diagnostic methods. Initial approaches focus on evaluating various underlying causes, including helminthic infections, adverse drug reactions, allergic diseases, and neoplastic diseases. When secondary causes of HE are excluded, the workup should proceed to the evaluation of primary/clonal bone marrow disease, including fip 1-like 1-platelet driven growth factor receptor alpha (FIP1L1-PDGFRA) mutation. Concurrently, if the patient has symptoms and signs, organ damage or dysfunction must be evaluated. Although, corticosteroids are the mainstay of therapy in confirmed HES, imatinib is considered a definitive treatment for FIP1L1-PDGFRA, platelet driven growth factor receptor beta rearranged HE and HES. In this article, we discuss recent advances in the classification of and practical approaches to HE and HES. In addition, we introduce several promising therapies for HE and HES.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Akuthota P / 2015 / Spectrum of eosinophilic end-organ manifestations / Immunol Allergy Clin North Am 35 : 403 ~ 411
Brigden M / 1997 / Eosinophilia detected by automated blood cell counting in ambulatory North American outpatients. Incidence and clinical significance / Arch Pathol Lab Med
Chusid MJ / 1975 / The hypereosinophilic syndrome : analysis of fourteen cases with review of the literature / Medicine(Baltimore) 54 : 1 ~ 27
Cools J / 2003 / A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome / N Engl J M
Curtis C / 2015 / Evaluation and differential diagnosis of persistent marked eosinophilia / Immunol Allergy Clin North Am 35 : 387 ~ 402
Brigden M / 1997 / Eosinophilia detected by automated blood cell counting in ambulatory North American outpatients. Incidence and clinical significance / Arch Pathol Lab Med
Chusid MJ / 1975 / The hypereosinophilic syndrome : analysis of fourteen cases with review of the literature / Medicine(Baltimore) 54 : 1 ~ 27
Cools J / 2003 / A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome / N Engl J M
Curtis C / 2015 / Evaluation and differential diagnosis of persistent marked eosinophilia / Immunol Allergy Clin North Am 35 : 387 ~ 402
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