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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제1호
- 발행연도
- 2015.1
- 수록면
- 37 - 43 (7page)
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Background: A few recent studies have demonstrated a possible role of transglutaminase 2 (TG2) in tumorigenesis or progression of renal cell carcinoma (RCC). The aim of this study was to examine TG2 expression and its clinicopathologic significance in a large number of human clear cell RCCs (CCRCCs). Methods: We analyzed 638 CCRCC patients who underwent partial or radical nephrectomy between 1995 and 2005. The expression of TG2 was determined by immunohistochemistry and categorized into four groups, according to staining intensity: negative (0), mild (1+), moderate (2+), and strong (3+). Results: TG2 staining intensity was negative in 8.5% of CCRCC (n=54), 1+ in 32.6% (n=208), 2+ in 50.5% (n=322), and 3+ in 8.5% (n=54). Strong TG2 expression was correlated with high Fuhrman nuclear grade (p=.011), high T category (p=.049), metastasis (p=.043) and male sex (p<.001) but not with N category.The survival analysis showed a significant association between strong TG2 expression and worse overall and cancer-specific survival (p=.027 and p=.010, respectively). On multivariate analysis, strong TG2 expression was a marginally significant prognostic indicator for Fuhrman nuclear grade and TNM staging (p=.054). Conclusions: Our study is the first to demonstrate the clinicopathologic significance of TG2 expression in a large number of human CCRCC samples. Strong TG2 expression was associated with high nuclear grade and poor prognosis.
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참고문헌 (26)
참고문헌 신청
Belkin AM / 2011 / Extracellular TG2 : emerging functions and regulation / Febs J 278 : 4704 ~ 4716
Collighan RJ / 2009 / Transglutaminase 2 cross-linking of matrix proteins : biological significance and medical applications / Amino Acids 36 : 659 ~ 670
Edge SB / 2010 / AJCC cancer staging manual / Springer
Erdem M / 2014 / Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma / Urol Oncol 32 : 25.e13 ~ 25.e20
Fok JY / 2006 / Implications of tissue transglutaminase expression in malignant melanoma / Mol Cancer Ther 5 : 1493 ~ 1503
Collighan RJ / 2009 / Transglutaminase 2 cross-linking of matrix proteins : biological significance and medical applications / Amino Acids 36 : 659 ~ 670
Edge SB / 2010 / AJCC cancer staging manual / Springer
Erdem M / 2014 / Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma / Urol Oncol 32 : 25.e13 ~ 25.e20
Fok JY / 2006 / Implications of tissue transglutaminase expression in malignant melanoma / Mol Cancer Ther 5 : 1493 ~ 1503
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