지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제2호
- 발행연도
- 2013.1
- 수록면
- 167 - 171 (5page)
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초록· 키워드
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Papillary thyroid carcinoma with nodular fasciitis-like stroma (PTC-NFS) is a rare variant of PTC. The term ‘PTC with fibromatosis-like stroma’ has been used as a synonym to describe this variant. It is characterized by extensive proliferation of fibroblasts and myofibroblasts in the tumor stroma, which occurs in up to 80% of the tumors. We herein describe a case of PTC-NFS which developed in a 49-year-old woman with the demonstration of findings of ultrasonography, fine needle aspiration cytology and histological examination of the lesion. To characterize the stromal components, we investigated the expression of several immunohistochemical markers which have been shown to be expressed differently in nodular fasciitis (NF) and fibromatosis (FM). The immunostaining results demonstrated nuclear and cytoplasmic accumulation of β-catenin, cytoplasmic transforming growth factor-β expression and nuclear Smad expression in the stromal cells, suggesting that the stromal cells in this case have similar molecular profiles to those of FM rather than NF.
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참고문헌 (14)
참고문헌 신청
Bacac M / 2006 / A gene expression signature that distinguishes desmoid tumours from nodular fasciitis / J Pathol 208 : 543 ~ 553
Carlson JW / 2007 / Immunohistochemistry for beta-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature / Histopat
Chan JK / 1991 / Papillary carcinoma of thyroid with exuberant nodular fasciitis-like stroma: report of three cases / Am J Clin Pathol 95 : 309 ~ 314
Inaba M / 2002 / Papillary thyroid carcinoma with fibromatosis-like stroma: a report of two cases / Endocr Pathol 13 : 219 ~ 225
Lee KW / 2010 / Sonographic finding of papillary thyroid carcinoma with nodular fasciitis-like stroma / J Med Ultrasonics 37 : 59 ~ 61
Carlson JW / 2007 / Immunohistochemistry for beta-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature / Histopat
Chan JK / 1991 / Papillary carcinoma of thyroid with exuberant nodular fasciitis-like stroma: report of three cases / Am J Clin Pathol 95 : 309 ~ 314
Inaba M / 2002 / Papillary thyroid carcinoma with fibromatosis-like stroma: a report of two cases / Endocr Pathol 13 : 219 ~ 225
Lee KW / 2010 / Sonographic finding of papillary thyroid carcinoma with nodular fasciitis-like stroma / J Med Ultrasonics 37 : 59 ~ 61
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