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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
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- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제1호
- 발행연도
- 2013.1
- 수록면
- 1 - 8 (8page)
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Preoperative radiotherapy may improve the resectability and subsequent local control of rectal cancers. However, the extent of radiation induced regression in these tumours varies widely between individuals. To date no reliable predictive marker of radiation sensitivity in rectal cancer has been identified. At the cellular level, radiation injury initiates a complex molecular network of DNA damage response (DDR) pathways that leads to cell cycle arrest, attempts at re-constituting the damaged DNA and should this fail, then apoptosis. This review presents the details which suggestthe roles of DNA mismatch repair proteins, the lack of which define a distinct subset of colorectal cancers with microsatellite instability (MSI), in the DDR pathways. Hence routine assessment of the MSI status in rectal cancers may potentially serve as a predictor of radiotherapy response, thereby improving patient stratification in the administration of this otherwise toxic treatment
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참고문헌 (72)
참고문헌 신청
Marijnen CA / 2005 / Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial / J Clin Oncol 23:1847~1858
Zlobec I / 2005 / A predictive model of rectal tumor response to preoperative radiotherapy using classification and regression tree methods / Clin Cancer Res 11:5440~5443
Rödel F / 2008 / Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models / Int J Radiat Oncol Biol Phys 71:247~255
Negroni A / 2008 / Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity / Int J Radiat Biol 84:265~276
Bengala C / 2009 / Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer / Ann Oncol 20:469~474
Zlobec I / 2005 / A predictive model of rectal tumor response to preoperative radiotherapy using classification and regression tree methods / Clin Cancer Res 11:5440~5443
Rödel F / 2008 / Survivin antisense oligonucleotides effectively radiosensitize colorectal cancer cells in both tissue culture and murine xenograft models / Int J Radiat Oncol Biol Phys 71:247~255
Negroni A / 2008 / Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity / Int J Radiat Biol 84:265~276
Bengala C / 2009 / Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer / Ann Oncol 20:469~474
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