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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제6호
- 발행연도
- 2012.1
- 수록면
- 532 - 540 (9page)
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Background: Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors, such as carbonic anhydrase IX (CA IX), glucose transporter-1 (GLUT-1), and vascular endothelial growth factor (VEGF) permit tumor cell adaptation to hypoxia. We attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis. Methods: Immunohistochemistry for CA IX, GLUT-1, and VEGF was performed on formalin-fixed, paraffin-embedded tissues from 125 cases of ovarian epithelial cancer (OEC). Results: CA IX expression was significantly associated with an endometrioid and mucinous histology,nuclear grade, tumor necrosis, and mitosis. GLUT-1 expression was associated with tumor necrosis and mitosis. VEGF expression was correlated only with disease recurrence. Expression of each marker was not significant in terms of overall survival in OECs; however, there was a significant correlation between poor overall survival rate and high coexpression of these markers. Conclusions: The present study suggests that it is questionable whether CA IX, GLUT-1, or VEGF can be used alone as independent prognostic factors in OECs. Using at least two markers helps to predict patient outcomes in total OECs. Moreover, the inhibition of two target gene combinations might prove to be a novel anticancer therapy.
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참고문헌 (23)
참고문헌 신청
Behrooz A / 1997 / Dual control of glut1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation / J Biol Chem 272 : 5555 ~ 5562
Cantuaria G / 2001 / GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy / Cancer 92 : 1144 ~ 1150
Ferrara N. / 1995 / The role of vascular endothelial growth factor in pathological angiogenesis / Breast Cancer Res Treat 36 : 127 ~ 137
Giatromanolaki A / 2001 / Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
Giatromanolaki A / 2001 / Tumour hypoxia, hypoxia signaling pathways and hypoxia inducible factor expression in human cancer / Anticancer Res 21 : 4317 ~ 4324
Cantuaria G / 2001 / GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy / Cancer 92 : 1144 ~ 1150
Ferrara N. / 1995 / The role of vascular endothelial growth factor in pathological angiogenesis / Breast Cancer Res Treat 36 : 127 ~ 137
Giatromanolaki A / 2001 / Expression of hypoxia-inducible carbonic anhydrase-9 relates to angiogenic pathways and independently to poor outcome in non-small cell lung cancer
Giatromanolaki A / 2001 / Tumour hypoxia, hypoxia signaling pathways and hypoxia inducible factor expression in human cancer / Anticancer Res 21 : 4317 ~ 4324
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