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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제2호
- 발행연도
- 2012.1
- 수록면
- 162 - 168 (7page)
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Background: Interleukin 31 (IL-31) is a T helper type 2 effector cytokine that plays an important role in the pathogenesis of atopic and allergic diseases. IL-31 may be involved in promoting allergic inflammation and in inducing airway epithelial responses such as allergic asthma. Methods: Single-base extension analysis was used to detect the genotypes of IL-31 single nucleotide polymorphisms (SNPs), and we compared the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Results: There were no significant differences in the genotype and allele frequencies of the IL-31 SNPs between patients with asthma and healthy controls. Furthermore we compared the genotype and allele frequencies of IL-31 SNPs between patients with atopic asthma, those with non-atopic asthma and healthy controls. This showed that the SNPs were not associated with the susceptibility to atopic asthma. There were no significant differences in the haplotype frequencies of IL-31 SNPs between patients with asthma and healthy controls. In patients with asthma, the IL-31 SNPs were significantly correlated with total serum levels of IgE (p=0.035). Conclusions: Our results indicate that, the IL-31 SNPs may be associated with IgE production in patients with asthma.
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참고문헌 (23)
참고문헌 신청
/ 1987 / Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. This official statement of the American Thoracic Soci
Abbas AK / 1996 / Functional diversity of helper T lymphocytes / Nature 383 : 787 ~ 793
Chae SC / 2007 / Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population / J Hum Genet 52 : 355 ~ 361
Chattopadhyay S / 2007 / Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells / J Biol Chem 282 : 3014 ~ 3026
Chiappara G / 2001 / Airway remodelling in the pathogenesis of asthma / Curr Opin Allergy Clin Immunol 1 : 85 ~ 93
Abbas AK / 1996 / Functional diversity of helper T lymphocytes / Nature 383 : 787 ~ 793
Chae SC / 2007 / Identification of polymorphisms in human interleukin-27 and their association with asthma in a Korean population / J Hum Genet 52 : 355 ~ 361
Chattopadhyay S / 2007 / Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells / J Biol Chem 282 : 3014 ~ 3026
Chiappara G / 2001 / Airway remodelling in the pathogenesis of asthma / Curr Opin Allergy Clin Immunol 1 : 85 ~ 93
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