지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제42권 제5호
- 발행연도
- 2008.1
- 수록면
- 251 - 259 (9page)
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초록· 키워드
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Background : JL1 is a novel antigen that has been reported to be expressed exclusively in immature CD4 CD8 double positive T-cells in the thymic cortex. Thymomas are often infiltrated with lymphocytes that are mostly immature T-cells. Methods : We evaluated 67 cases of surgically resected thymomas and reviewed their histological, surgical, and clinical findings. Representative sections were immunostained using anti-JL1 monoclonal antibody and the
immunostaining score was evaluated in each case. Results : JL1 was strongly positive in immature T cells infiltrated in various subtypes of thymomas. The mean value of the immunostaining score was 0 for type A, 0.24 for the A areas of type AB, 2.71 for the B areas of type AB, 3 for type B1, 1.87 for type B2, 0.67 for type B3, and 0.13 for type C. The immunostaining score correlated with the histological subtypes according to the WHO classification, and stages according to the modified Masaoka system. Conclusions : JL1 was specifically detected in immature thymocytes in thymomas. Therefore, JL1 immunostaining can be useful for subtyping thymomas. JL1 can also serve as an adjunctive marker to diagnose thymomas in small biopsy specimens.
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참고문헌 (24)
참고문헌 신청
Ashton-Rickardt PG / 1994 / A differential-avidity model for T-cell selection / Immunol Today 15 : 362 ~ 366
Chan JK / 1995 / The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors / Am J Surg Pathol 19 : 1115 ~ 1123
Chan JK / 2007 / Tumor of the lymphoreticular system. In: Fletcher CDM, ed. Diagnostic Histopathology of Tumors. 3rd ed / Churchill Livingstone : 1317 ~ 1330
Dawson A / 1994 / Observer variation in the histopathological classification of thymoma: correlation with prognosis / J Clin Pathol 47 : 519 ~ 523
Fujii Y / 1999 / Flow cytometric study of lymphocytes associated with thymoma and other thymic tumors / J Surg Res 82 : 312 ~ 318
Chan JK / 1995 / The MIC2 antibody 013. Practical application for the study of thymic epithelial tumors / Am J Surg Pathol 19 : 1115 ~ 1123
Chan JK / 2007 / Tumor of the lymphoreticular system. In: Fletcher CDM, ed. Diagnostic Histopathology of Tumors. 3rd ed / Churchill Livingstone : 1317 ~ 1330
Dawson A / 1994 / Observer variation in the histopathological classification of thymoma: correlation with prognosis / J Clin Pathol 47 : 519 ~ 523
Fujii Y / 1999 / Flow cytometric study of lymphocytes associated with thymoma and other thymic tumors / J Surg Res 82 : 312 ~ 318
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