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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제38권 제3호
- 발행연도
- 2004.1
- 수록면
- 145 - 156 (12page)
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초록· 키워드
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Background : The captopril reduces radiation induced lung injury and fibrosis. We designed a
study to evaluate the antifibrogenic effect of Captopril in radiation induced lung injury. Methods :
Fifty Sprague-Dawley rats were divided into radiation group (I) (n=30) and radiation plus captopril
group (II) (n=15). The rats were sacrificed at 12 hours and 11 weeks after radiation. We
examined light microscopic, immunohistochemical and electron microscopic features in each
groups. Results : In Group I, the lungs showed acute lung injury at 12 h. The lungs showed patchy
fibrosis with collagen deposits at 11 weeks. The severity of the alveolar injury and fibrosis was
correlated with radiation doses. The Group II showed less severe lung fibrosis than Group I.
The mean numbers of mast cells and myofibroblasts of Group II were lower than Group I (p<
0.05). The TNF- and TGF- were higher expressed according to radiation doses in Group
I, and less prominent in Group II. Ultrastructurally, the alveolar cell injury and fibrosis were less
severe in Group II. The TUNEL stains showed higher expressions according to radiation doses
in Group I, and expressed in Group II. Conclusions : The captopril decreases the number of
mast cells and myofibroblasts, reduces collagen deposition and apoptosis of alveolar cells in
rat lungs after radiation, and so reduces the degree of pulmonary injury and fibrosis.
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참고문헌 (28)
참고문헌 신청
[학술지(정기간행물
/ / Captopril inhibits proliferationof human lung fibroblasts in culture: : 80 ~ 4
/ / Changes in plasma TGFlevelsduring pulmonary radiotherapy as a predictor of the risk ofdeveloping radiation pneumonitis : 671 ~ 6
/ / Early alterations in extracellularmatrix and transforming growth factor gene expression inmouse lung indicative of late radiation fibrosis : 621 ~ 31
/ / Effect of captopril on mortalityand morbidity in patients with left ventricular dysfunction aftermyocardial infarction : 669 ~ 77
/ / Captopril inhibits proliferationof human lung fibroblasts in culture: : 80 ~ 4
/ / Changes in plasma TGFlevelsduring pulmonary radiotherapy as a predictor of the risk ofdeveloping radiation pneumonitis : 671 ~ 6
/ / Early alterations in extracellularmatrix and transforming growth factor gene expression inmouse lung indicative of late radiation fibrosis : 621 ~ 31
/ / Effect of captopril on mortalityand morbidity in patients with left ventricular dysfunction aftermyocardial infarction : 669 ~ 77
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