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자료유형
학술저널
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대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제36권 제2호
발행연도
2002.1
수록면
93 - 99 (7page)

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With the widespread use of high resolution ultrasound in early pregnancy periods, poorly formed diagnostic features of complete hydatidiform mole (CHM) (which mimics normal or nonmolar gestation) often lead to a confusion of CHM with partial mole, hydropic abortion or nonmolar chromosomal abnormalities. Methods : We studied the clinicopathologic findings in 51 early CHM, evacuated before 12 weeks of gestation to characterize the early histologic changes. Results : Conventional diagnostic features were not uniformly identified; extensive cavitation was identified in 51.0%, trophoblastic hyperplasia in 49.1%, and avascular villi in 13.7%. The characteristic histologic features of early CHM were cellular and basophilic stroma (82.4%), bulbous projection with linear intervening clefts (76.5%), and apoptotic stromal cells (84.3%). In 86.3%, vascularized chorionic villi showed either primitive vascular network or clearly visible vascular lumen. Nonmetastatic persistent trophoblastic neoplasia developed in 35.3% and all were cured with single-agent or combination chemotherapy. Choriocarcinoma did not develop in any cases. The extent of trophoblastic proliferation at initial curettage had no prognostic value for clinical progression to persistent hydatidiform mole. Conclusions : The fact that the histologic features of CHM in early gestation are often not as distinctive as those in later gestation should always be kept in mind in the diagnosis of conceptual products in early gestation.

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