지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제6호
- 발행연도
- 2013.1
- 수록면
- 526 - 533 (8page)
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초록· 키워드
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Background: Absolute lymphocyte count (ALC) in peripheral blood has recently been reported to be an independent prognostic factor in multiple myeloma (MM). Previous studies indicated that the absolute monocyte count (AMC) in peripheral blood reflects the state of the tumor microenvironment in lymphomas. Neither the utility of the AMC nor its relationship with ALC has been studied in MM. Methods: The prognostic value of ALC, AMC, and the ALC/AMC ratio at the time of diagnosis was retrospectively examined in 189 patients with MM. Results: On univariate analysis, low ALC (<1,400 cells/μL), high AMC (≥490 cells/μL), and low ALC/AMC ratio (<2.9) were correlated with worse overall survival (OS) (p=.002, p=.038, and p=.001, respectively). On multivariate analysis, the ALC/AMC ratio was an independent prognostic factor (p=.047), whereas ALC and AMC were no longer statistical significant. Low ALC, high AMC, and low ALC/AMC ratio were associated with poor prognostic factors such as high International Staging System stage, plasmablastic morphology, hypoalbuminemia, and high β2-microglobulin. Conclusions: Univariate analysis demonstrated that changes in ALC, AMC, and the ALC/AMC ratio are associated with patient survival in MM. Multivariate analysis showed that, of these factors, the ALC/AMC ratio was an independent prognostic factor for OS.
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참고문헌 (30)
참고문헌 신청
Scavelli C / 2008 / Vasculogenic mimicry by bone marrow macrophages in patients with multiple myeloma / Oncogene 27:663~674
Berardi S / 2013 / Multiple myeloma macrophages: pivotal players in the tumor microenvironment / J Oncol 2013:183602
Vacca A / 1999 / Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma / Blood 93:3064~3073
Zheng Y / 2009 / Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis / Blood 114:3625~3628
Ben-Baruch A. / 2006 / Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators / Semin Cancer Biol 16:38~52
Berardi S / 2013 / Multiple myeloma macrophages: pivotal players in the tumor microenvironment / J Oncol 2013:183602
Vacca A / 1999 / Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma / Blood 93:3064~3073
Zheng Y / 2009 / Macrophages are an abundant component of myeloma microenvironment and protect myeloma cells from chemotherapy drug-induced apoptosis / Blood 114:3625~3628
Ben-Baruch A. / 2006 / Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators / Semin Cancer Biol 16:38~52
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