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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제52권 제4호
- 발행연도
- 2018.1
- 수록면
- 262 - 266 (5page)
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초록· 키워드
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Rhabdomyosarcoma is a malignant soft tissue tumor which shows skeletal muscle differentiation. Leptomeningeal metastasis can occur as a late complication, but currently there are no reports that have documented the cytologic features in cerebrospinal fluid (CSF). We report a case of metastatic alveolar rhabdomyosarcoma diagnosed in the CSF of a 28-year-old male who was originally diagnosed with rhabdomyosarcoma on the neck, and that went through systemic therapy. The tumor was positive for anaplastic lymphoma kinase, but progressed despite additional therapy with crizotinib. The CSF specimen revealed small round cells, large atypical cells with abundant cytoplasm and eccentric nuclei, and cells with horseshoe-shaped nuclei. These cytologic findings were in agreement with previous literature and well-correlated with histopathology. This is the first report to document the cytologic feature of rhabdomyosarcoma in CSF. In many cases it is difficult to perform ancillary tests in a CSF specimen and cytopathologists should be aware of the cytomorphologic characteristics to avoid misdiagnosis.
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참고문헌 (17)
참고문헌 신청
Dagher R / 1999 / Rhabdomyosarcoma: an overview / Oncologist 4:34~44
Parham DM / 2006 / Rhabdomyosarcomas in adults and children: an update / Arch Pathol Lab Med 130:1454~1465
De B / 2017 / Central nervous system relapse of rhabdomyosarcoma / Pediatr Blood Cancer
Jaeckle KA / 2006 / Neoplastic meningitis from systemic malignancies: diagnosis, prognosis and treatment / Semin Oncol 33:312~323
Thiryayi SA / 2010 / Diagnosis of alveolar rhabdomyosarcoma in effusion cytology: a diagnostic pitfall / Cytopathology 21:273~275
Parham DM / 2006 / Rhabdomyosarcomas in adults and children: an update / Arch Pathol Lab Med 130:1454~1465
De B / 2017 / Central nervous system relapse of rhabdomyosarcoma / Pediatr Blood Cancer
Jaeckle KA / 2006 / Neoplastic meningitis from systemic malignancies: diagnosis, prognosis and treatment / Semin Oncol 33:312~323
Thiryayi SA / 2010 / Diagnosis of alveolar rhabdomyosarcoma in effusion cytology: a diagnostic pitfall / Cytopathology 21:273~275
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