지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제1호
- 발행연도
- 2012.1
- 수록면
- 42 - 47 (6page)
이용수
초록· 키워드
오류제보하기
Background: Distinguishing small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC) of the lung is difficult with little information about interobserver variability. Methods: One hundred twenty-nine cases of resected SCLC and LCNEC were independently evaluated by four pathologists and classified according to the 2004 World Health Organization criteria. Agreement was regarded as “unanimous” if all four pathologists agreed on the classification. The kappa statistic was calculated to measure the degree of agreement between pathologists. We also measured cell size using image analysis, and receiver-operating-characteristic curve analysis was performed to evaluate cell size in predicting the diagnosis of high-grade neuroendocrine (NE) carcinomas in 66 cases. Results: Unanimous agreement was achieved in 55.0% of 129 cases. The kappa values ranged from 0.35 to 0.81. Morphometric analysis reaffirmed that there was a continuous spectrum of cell size from SCLC to LCNEC and showed that tumors with cells falling in the middle size range were difficult to categorize and lacked unanimous agreement. Conclusions: Our results provide an objective explanation for considerable interobserver variability in the diagnosis of high-grade pulmonary NE carcinomas. Further studies would need to define more stringent and objective definitions of cytologic and architectural characteristics to reliably distinguish between SCLC and LCNEC.
목차
등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Asamura H / 2006 / Neuroendocrine neoplasms of the lung: a prognostic spectrum / J Clin Oncol 24 : 70 ~ 76
Marchevsky AM / 2001 / Morphometry confirms the presence of considerable nuclear size overlap between “small cells” and “large cells” in high-grade pulmonary neuroendocri
Travis WD / 1991 / Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma: an ultrastructural, immunohistochemical, and flow cytomet
Travis WD / 1998 / Reproducibility of neuroendocrine lung tumor classification / Hum Pathol 29 : 272 ~ 279
Travis WD / 2004 / World Health Organization classification of tumour: pathology and genetics of tumours of the lung, pleura, thymus and heart / IARC Press
Marchevsky AM / 2001 / Morphometry confirms the presence of considerable nuclear size overlap between “small cells” and “large cells” in high-grade pulmonary neuroendocri
Travis WD / 1991 / Neuroendocrine tumors of the lung with proposed criteria for large-cell neuroendocrine carcinoma: an ultrastructural, immunohistochemical, and flow cytomet
Travis WD / 1998 / Reproducibility of neuroendocrine lung tumor classification / Hum Pathol 29 : 272 ~ 279
Travis WD / 2004 / World Health Organization classification of tumour: pathology and genetics of tumours of the lung, pleura, thymus and heart / IARC Press
이 논문의 저자 정보
최근 본 자료
댓글(0)
0