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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제5호
- 발행연도
- 2011.1
- 수록면
- 445 - 454 (10page)
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초록· 키워드
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Background: Decay accelerating factor (DAF/CD55), regulates the complement system by accelerating decay of the C3 convertase, has been described in several malignancies, however, the clinicopathologic significance of CD55 and its receptor CD97 has not been fully investigated. We examined the expression patterns of both CD55 and CD97 and their association with clinicopathologic parameters in colorectal cancers (CRCs). Methods: Expression patterns of CD55 and CD97 in the stroma and tumor cells at tumor center and invasive front were examined in 130 CRCs, and their significance was statistically evaluated. Results: CD55-high stroma was correlated with tumor border (p=0.006) and invasion depth (p=0.013). CD55-high tumor cells at tumor center and invasive front were correlated with histologic grade, and CD55-high tumor cells at invasive front with tumor, node and metastasis (TNM) stage (p<0.05). CD97-high stroma was correlated with lymph node metastasis (p=0.016) and TNM stage (p=0.030). CD97-high tumor cells at tumor center and invasive front were correlated with tumor size and CD97-high tumor cells at tumor center with tumor border (p<0.05). Patients with CD55-high stroma showed poor overall and recurrence-free survival (p<0.05) in univariate analysis, and were independently associated with short recurrence-free survival (p=0.025) in multivariate analysis. Conclusions: Stromal CD55 overexpression would be an indicator of adverse clinical outcome and a useful prognostic factor.
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참고문헌 (29)
참고문헌 신청
Durrant LG / 2003 / Enhanced expression of the complement regulatory protein CD55 predicts a poor prognosis in colorectal cancer patients / Cancer Immunol Immunother 52:638~642
Ogane N / 2010 / Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma / Ann Diagn Pathol 14:23~29
Watson NF / 2006 / Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis / Int J Cancer 118:6~10
Sulkowska M / 2009 / Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients / Pathology 41:254~260
Portyanko A / 2009 / Beta(III)-tubulin at the invasive margin of colorectal cancer: possible link to invasion / Virchows Arch 454:541~548
Ogane N / 2010 / Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma / Ann Diagn Pathol 14:23~29
Watson NF / 2006 / Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis / Int J Cancer 118:6~10
Sulkowska M / 2009 / Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients / Pathology 41:254~260
Portyanko A / 2009 / Beta(III)-tubulin at the invasive margin of colorectal cancer: possible link to invasion / Virchows Arch 454:541~548
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