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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제5호
- 발행연도
- 2011.1
- 수록면
- 477 - 484 (8page)
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초록· 키워드
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Background: The incidence of papillary thyroid carcinoma (PTC) has been increasing recently and a precise diagnosis is essential for optimal treatment. Ancillary immunohistochemical stains are important for diagnosing some difficult cases. Methods: The dignostic value of CD56, high molecular weight cytokeratin (HMCK), galectin-3 (GAL3), and cytokeratin 19 (CK19) were evaluated to distinguish PTC from other benign thyroid lesions (BTL). We studied 23 cases of papillary thyroid overt carcinomas, 57 papillary thyroid microcarcinomas, five follicular adenomas, five cases of Hashimoto’s thyroiditis, and 12 nodular hyperplasias. Results: The statistical analysis showed significantly different expressions of CD56, HMCK, GAL3, and CK19 in PTC vs other BTL. The diagnostic specificity of HMCK and CD56 (90.9% and 72.7%, respectively) was higher than that of GAL3 and CK19 (50.0% and 36.4%, respectively). However, the sensitivity of HMCK and CD56 detection (92.5% and 95.0%, respectively) was lower than that of GAL3 and CK19 (98.8% and 100.0%, respectively). The combined use of CD56, HMCK, GAL3, and CK19 showed 87.5% sensitivity, 100.0% specificity, and 100.0% positive predictive value in differentiating PTC from other BTL. Conclusions: Although the differential diagnosis of thyroid follicular lesions are based on histological and cytomorphological criteria, CD56 and HMCK might be useful markers for diagnosing PTC.
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참고문헌 (19)
참고문헌 신청
Bernet VJ / 2002 / Determination of galectin-3 messenger ribonucleic acid overexpression in papillary thyroid cancer by quantitative reverse transcription-polymerase chain r
El Demellawy D / 2008 / Application of CD56, p63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid / Diagn Pathol 3 : 5 ~
El Demellawy D / 2009 / Diagnostic utility of CD56 immunohistochemistry in papillary carcinoma of the thyroid / Pathol Res Pract 205 : 303 ~ 309
Kim SK / 2011 / Surgical results of thyroid nodules according to a management guideline based on the BRAF(V600E) mutation status / J Clin Endocrinol Metab 96 : 658 ~ 664
Liberman E / 2000 / Papillary and follicular neoplasms of the thyroid gland: differential immunohistochemical staining with high- molecular-weight keratin and involucrin / Ap
El Demellawy D / 2008 / Application of CD56, p63 and CK19 immunohistochemistry in the diagnosis of papillary carcinoma of the thyroid / Diagn Pathol 3 : 5 ~
El Demellawy D / 2009 / Diagnostic utility of CD56 immunohistochemistry in papillary carcinoma of the thyroid / Pathol Res Pract 205 : 303 ~ 309
Kim SK / 2011 / Surgical results of thyroid nodules according to a management guideline based on the BRAF(V600E) mutation status / J Clin Endocrinol Metab 96 : 658 ~ 664
Liberman E / 2000 / Papillary and follicular neoplasms of the thyroid gland: differential immunohistochemical staining with high- molecular-weight keratin and involucrin / Ap
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