지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제48권 제1호
- 발행연도
- 2014.1
- 수록면
- 30 - 35 (6page)
이용수
초록· 키워드
오류제보하기
Background: This study was aimed at investigating the relation of P2X7 receptor (P2X7R) expression with the clinicopathological features of papillary thyroid carcinoma (PTC) coexisting with Hashimoto’s thyroiditis (HT). Methods: We examined 170 patients (84, PTC with HT; 86, PTC without HT). P2X7R expression was examined by immunohistochemical methods. The staining intensity and patterns were evaluated and scored using a semi-quantitative method. Results: The PTC with HT group was more likely to contain women and had less extrathyroid extension, lymph node (LN) metastasis, lymphovascular invasion, and recurrence than the PTC without HT group. Patients positive for P2X7R had significantly higher frequencies of lymphovascular invasion, extrathyroid extension, LN metastasis, and absence of HT. As shown by multivariate analysis, the expression of P2X7R was significantly higher if HT was absent and extrathyroid extension was present. In the PTC with HT group, the expression of P2X7R was significantly higher in patients with tumor multifocality, lymphovascular invasion, and extrathyroid extension. In the PTC without HT group, the expression of P2X7R was significantly higher in women and those having tumor multifocality. Conclusions: Coexistence of PTC with HT is associated with good prognostic factors, and P2X7Rexpression in PTC was correlated with poor prognostic factors and the absence of HT.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Beynon V / 2012 / Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling / PLoS One 7 : e3957
Chistiakov DA / 2005 / Immunogenetics of Hashimoto’s thyroiditis / J Autoimmune Dis 2 : 1 ~
Dardano A / 2009 / 1513A>C polymorphism in the P2X7 receptor gene in patients with papillary thyroid cancer: correlation with histological variants and clinical parameter
Del Rio P / 2008 / The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? / Minerva Endocrinol 33 : 1 ~ 5
Giordano C / 1997 / Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto’s thyroiditis / Science 275 : 960 ~ 963
Chistiakov DA / 2005 / Immunogenetics of Hashimoto’s thyroiditis / J Autoimmune Dis 2 : 1 ~
Dardano A / 2009 / 1513A>C polymorphism in the P2X7 receptor gene in patients with papillary thyroid cancer: correlation with histological variants and clinical parameter
Del Rio P / 2008 / The association between papillary carcinoma and chronic lymphocytic thyroiditis: does it modify the prognosis of cancer? / Minerva Endocrinol 33 : 1 ~ 5
Giordano C / 1997 / Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto’s thyroiditis / Science 275 : 960 ~ 963
이 논문의 저자 정보
최근 본 자료
댓글(0)
0