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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제5호
- 발행연도
- 2013.1
- 수록면
- 458 - 465 (8page)
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Background: A clonality test for immunoglobulin (IG) and T cell receptor (TCR) is a useful adjunctive method for the diagnosis of lymphoproliferative diseases (LPDs). Recently, the BIOMED-2 multiplex polymerase chain reaction (PCR) assay has been established as a standard method for assessing the clonality of LPDs. We tested clonality in LPDs in Koreans using the BIOMED-2 multiplex PCR and compared the results with those obtained in European, Taiwanese, and Thai participants. We also evaluated the usefulness of the test as an ancillary method for diagnosing LPDs. Methods: Two hundred and nineteen specimens embedded in paraffin, including 78 B cell lymphomas, 80 T cell lymphomas and 61 cases of reactive lymphadenitis, were used for the clonality test. Results: Mature B cell malignancies showed 95.7% clonality for IG, 2.9% co-existing clonality, and 4.3% polyclonality. Mature T cell malignancies exhibited 83.8% clonality for TCR, 8.1% co-existing clonality, and 16.2% polyclonality. Reactive lymphadenitis showed 93.4% polyclonality for IG and TCR. The majority of our results were similar to those obtained in Europeans. However, the clonality for IGK of B cell malignancies and TCRG of T cell malignancies was lower in Koreans than Europeans. Conclusions: The BIOMED-2 multiplex PCR assay was a useful adjunctive method for diagnosing LPDs.
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참고문헌 (20)
참고문헌 신청
Achille A / 1995 / Routine application of polymerase chain reaction in the diagnosis of monoclonality of B-cell lymphoid proliferations / Diagn Mol Pathol 4 : 14 ~ 24
Benhattar J / 1995 / Improved polymerase chain reaction detection of clonal T-cell lymphoid neoplasms / Diagn Mol Pathol 4 : 108 ~ 112
Bruggemann M / 2007 / Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-393
Chen YL / 2010 / BIOMED-2 protocols to detect clonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell lymphomas in southern Taiwan / Leuk Lymphoma 51
Cho EY / 2001 / Diagnostic utility of polymerase chain reaction-based clonality analysis for immunoglobulin heavy chain gene and T-cell receptor gamma chain gene rearrangemen
Benhattar J / 1995 / Improved polymerase chain reaction detection of clonal T-cell lymphoid neoplasms / Diagn Mol Pathol 4 : 108 ~ 112
Bruggemann M / 2007 / Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies Report of the BIOMED-2 Concerted Action BHM4 CT98-393
Chen YL / 2010 / BIOMED-2 protocols to detect clonal immunoglobulin and T-cell receptor gene rearrangements in B- and T-cell lymphomas in southern Taiwan / Leuk Lymphoma 51
Cho EY / 2001 / Diagnostic utility of polymerase chain reaction-based clonality analysis for immunoglobulin heavy chain gene and T-cell receptor gamma chain gene rearrangemen
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