지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제5호
- 발행연도
- 2013.1
- 수록면
- 433 - 442 (10page)
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초록· 키워드
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Background: The aim of this study is to evaluate the histologic features of metastatic neuroblastic tumors (NTs) in bone marrow (BM) before and after chemotherapy in comparison with those of primary NTs. Methods: A total of 294 biopsies from 48 children diagnosed with NTs with BM metastasis were examined. There were 48 primary neoplasm biopsies, 48 BM biopsies before chemotherapy, 36 primary neoplasm excisional biopsies after chemotherapy, and 162 BM biopsies after chemotherapy. Results: Metastatic NTs in BM before chemotherapy were composed of undifferentiated and/or differentiating neuroblasts, but had neither ganglion cells nor Schwannian stroma. Metastatic foci of BM after chemotherapy were found to have differentiated into ganglion cells or Schwannian stroma, which became more prominent after further cycles of chemotherapy. Persistence of NTs or tumor cell types in BM after treatment did not show statistically significant correlation to patients’ outcome. However, three out of five patients who newly developed poorly differentiated neuroblasts in BM after treatment expired due to disease progression. Conclusions: Metastatic NTs in BM initially consist of undifferentiated or differentiating neuroblasts regardless of the primary tumor subtype, and become differentiated after chemotherapy. Newly appearing poorly differentiated neuroblasts after treatment might be an indicator for poor prognosis.
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참고문헌 (24)
참고문헌 신청
Ambros IM / 1996 / Role of ploidy, chromosome 1p, and Schwann cells in the maturation of neuroblastoma / N Engl J Med 334 : 1505 ~ 1511
Bernstein ML / 1992 / A population-based study of neuroblastoma incidence, survival, and mortality in North America / J Clin Oncol 10 : 323 ~ 329
Burgues O / 2006 / Prognostic value of the International Neuroblastoma Pathology Classification in Neuroblastoma (Schwannian stroma-poor) and comparison with other prognosti
Chatten J / 1988 / Prognostic value of histopathology in advanced neuroblastoma: a report from the Childrens Cancer Study Group / Hum Pathol 19 : 1187 ~ 1198
Cohn SL / 2009 / The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report / J Clin Oncol 27 : 289 ~ 297
Bernstein ML / 1992 / A population-based study of neuroblastoma incidence, survival, and mortality in North America / J Clin Oncol 10 : 323 ~ 329
Burgues O / 2006 / Prognostic value of the International Neuroblastoma Pathology Classification in Neuroblastoma (Schwannian stroma-poor) and comparison with other prognosti
Chatten J / 1988 / Prognostic value of histopathology in advanced neuroblastoma: a report from the Childrens Cancer Study Group / Hum Pathol 19 : 1187 ~ 1198
Cohn SL / 2009 / The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report / J Clin Oncol 27 : 289 ~ 297
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