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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제5호
- 발행연도
- 2012.1
- 수록면
- 463 - 469 (7page)
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Background: High-risk human papillomavirus (HR-HPV) infection and abnormal p53 expression are closely involved in carcinogenesis of squamous cell carcinoma (SqCC) of uterine cervix. Recent studies have suggested that virus-induced endoplasmic reticulum (ER) stress modulates various cell survival and cell death signaling pathways. The C/EBP homologous protein (CHOP) is associated with ER stress-mediated apoptosis and is also involved in carcinogenesis of several human cancers. We hypothesized that CHOP is involved in the carcinogenesis of uterine cervical cancer in association with HR-HPV and/or p53. Methods: Immunohistochemistry was used to analyze CHOP and p53 protein expression of tissue sections from 191 patients with invasive cancer or preinvasive lesions of the uterine cervix (61 cases of SqCC, 66 cases of cervical intraepithelial neoplasia [CIN] III, and 64 cases of CIN I). Results: CHOP was expressed in 59.4% of CIN I, 48.5% of CIN III, and 70.5% of SqCC cases. It was also significantly more frequent in invasive SqCC than in preinvasive lesions (p=0.042). Moreover, CHOP expression significantly correlated with HR-HPV infection and p53 expression (p=0.009 and p=0.038, respectively). Conclusions: Our results suggest that CHOP is involved in the carcinogenesis of the uterine cervix SqCC via association with HR-HPV and p53.
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참고문헌 (25)
참고문헌 신청
Boyle P / 2005 / Cancer incidence and mortality in Europe, 2004 / Ann Oncol 16 : 481 ~ 488
Buitrago-Perez A / 2009 / Garcia-Escudero R. Molecular signature of HPV-induced carcinogenesis: pRb, p53 and gene expression profiling / Curr Genomics 10 : 26 ~ 34
Crozat A / 1993 / Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma / Nature 363 : 640 ~ 644
De Marco F / 2012 / Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues / PLoS One 7 : 34366 ~
Forus A / 1994 / The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas / Cancer Genet Cytogenet 78 : 1
Buitrago-Perez A / 2009 / Garcia-Escudero R. Molecular signature of HPV-induced carcinogenesis: pRb, p53 and gene expression profiling / Curr Genomics 10 : 26 ~ 34
Crozat A / 1993 / Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma / Nature 363 : 640 ~ 644
De Marco F / 2012 / Oxidative stress in HPV-driven viral carcinogenesis: redox proteomics analysis of HPV-16 dysplastic and neoplastic tissues / PLoS One 7 : 34366 ~
Forus A / 1994 / The protooncogene CHOP/GADD153, involved in growth arrest and DNA damage response, is amplified in a subset of human sarcomas / Cancer Genet Cytogenet 78 : 1
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