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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제46권 제5호
- 발행연도
- 2012.1
- 수록면
- 429 - 435 (7page)
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초록· 키워드
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Background: Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. In this study, we investigated the expression of MUC1 and MUC4 and their prognostic significance in gallbladder adenocarcinoma. Methods: We examined 54 surgical gallbladder adenocarcinoma samples by immunohistochemistry for MUC1 and MUC4 expression. Staining was evaluated as a sum score of extent and intensity, dividing the samples into low and high expression groups. Results: The low expression group for both MUC1 and MUC4 was 10 samples (18.5%), and the high expression group was 44 samples (81.5%). High MUC1 expression was significantly correlated with more differentiated tumors (p=0.033), whereas high expression of MUC4 correlated with negative nodal status (p=0.012). Other pathological features were not correlated with MUC expression. Multivariate cox regression analysis showed that neither MUC1 nor MUC4 expression correlated with survival. Conclusions: Although there were some correlations found, a prognostic role for either MUC1 or MUC4 expression in gallbladder carcinoma was not identified in this study. Further investigation is required.
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참고문헌 (24)
참고문헌 신청
Albrecht H / 2011 / MUC1 and MUC4: switching the emphasis from large to small / Cancer Biother Radiopharm 26 : 261 ~ 271
Ghosh M / 2005 / MUC 1 core protein as a marker of gallbladder malignancy / Eur J Surg Oncol 31 : 891 ~ 896
Hanada K / 1999 / Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct / Am J Gastroenterol 94 :
Hattrup CL / 2006 / MUC1 alters oncogenic events and transcription in human breast cancer cells / Breast Cancer Res 8 : 37 ~
Higashi M / 1999 / Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma
Ghosh M / 2005 / MUC 1 core protein as a marker of gallbladder malignancy / Eur J Surg Oncol 31 : 891 ~ 896
Hanada K / 1999 / Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct / Am J Gastroenterol 94 :
Hattrup CL / 2006 / MUC1 alters oncogenic events and transcription in human breast cancer cells / Breast Cancer Res 8 : 37 ~
Higashi M / 1999 / Expression of MUC1 and MUC2 mucin antigens in intrahepatic bile duct tumors: its relationship with a new morphological classification of cholangiocarcinoma
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