지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제6호
- 발행연도
- 2009.1
- 수록면
- 523 - 527 (5page)
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초록· 키워드
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Background : Tumor budding is present in the stroma at the invasive margin of colorectal carcinomas (CRC). The disintegration of cell adhesion molecules is closely related to this process. This study investigated the role of tumor budding in the progression of CRC, and compared the expression of β-catenin and E-cadherin between tumor budding and tumor center to determine whether epithelial-to-mesenchymal transitions (EMTs) occur in tumor budding. Methods : The number of tumor budding (NTB) instances was determined in 58 cases of CRC, and immunoreactivities of E-cadherin and β-catenin were compared at the tumor center and at the tumor budding site. Immunohistochemical staining for vimentin was also done. Results : Tumor budding was seen in 52 tumors (90%). There were significant associations between NTB and cliniopathologic parameters such as tumor depth, nodal metastasis and clinical stage. Expression of cytoplasmic and nuclear β-catenin were significantly higher at tumor budding sites than in the tumor center. In contrast, expression of membranous and cytoplasmic E-cadherin were significantly higher in the tumor center than at the tumor budding sites. Vimentin was expressed at tumor budding foci of only 2 cases (3%). Conclusions : This study suggests that EMT occurs at tumor budding, and that NTB may be a good marker for predicting a poor prognosis in CRC.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Barth AI / 1997 / Cadherins, catenins and APC protein:interplay between cytoskeletal complexes and signaling pathways / Curr Opin Cell Biol 9 : 683 ~ 690
Bellovin DI / 2005 / Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease / Cancer Res 65
Brabletz T / 1998 / Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front / Pathol Res Pract 194 : 701
Brabletz T / 1999 / beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer / Am J Pathol 155 : 1033 ~ 1038
Brabletz T / 2001 / Variable b-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment / Proc Natl Acad Sci : 10356 ~ 10361
Bellovin DI / 2005 / Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease / Cancer Res 65
Brabletz T / 1998 / Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front / Pathol Res Pract 194 : 701
Brabletz T / 1999 / beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer / Am J Pathol 155 : 1033 ~ 1038
Brabletz T / 2001 / Variable b-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment / Proc Natl Acad Sci : 10356 ~ 10361
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