지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제6호
- 발행연도
- 2011.1
- 수록면
- 573 - 581 (9page)
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초록· 키워드
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Background: Programmed death-1 (PD-1) is physiologically expressed by germinal center-asso-ciated helper T-cells and has an inhibitory effect on T-cell activity. Methods: We examined 63 cas¬es of diffuse large B-cell lymphoma (DLBCL) and determined the number of PD-1-positive helper T-cells in a representative tumor area after immunohistochemical staining using a monoclonal an¬tibody against PD-1. The PD-1-positive cells were counted in 3 high-power fields (HPFs; 400×). Results: Patients were divided into 2 groups: one with a high number of PD-1-positive cells (>20/HPF, n=33) and one with a low number of PD-1-positive cells (≤20/HPF, n=30). The for¬mer group showed decreased overall survival, but at a statistically non-significant level (p=0.073). A high number of PD-1-positive cells was more common in patients at an advanced clinical stage and with high international prognostic index score (p=0.025 and p=0.026, respectively). The number of extranodal sites also somewhat correlated with the PD-1 staining status (p=0.071). However, the number of PD-1-positive cells was not associated with patient age, serum lactate dehydrogenase level, and Eastern Cooperative Oncology Group performance score. Conclusions: The high number of PD-1-positive cells might be associated with an unfavorable outcome in DL¬BCL patients.
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참고문헌 (23)
참고문헌 신청
/ 1993 / A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project / N Engl J Med 329 : 987 ~ 994
/ 1997 / A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The Non-Hodgkin’s Lymphoma Classification Project / Blood
Alizadeh AA / 2000 / Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling / Nature 403 : 503 ~ 511
Bairey O / 1999 / Bcl-2, Bcl-X, Bax, and Bak expression in short- and long-lived patients with diffuse large B-cell lymphomas / Clin Cancer Res 5 : 2860 ~ 2866
Barrans SL / 2002 / Germinal center phenotype and bcl-2 expression combined with the International Prognostic Index improves patient risk stratification in diffuse large B-c
/ 1997 / A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. The Non-Hodgkin’s Lymphoma Classification Project / Blood
Alizadeh AA / 2000 / Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling / Nature 403 : 503 ~ 511
Bairey O / 1999 / Bcl-2, Bcl-X, Bax, and Bak expression in short- and long-lived patients with diffuse large B-cell lymphomas / Clin Cancer Res 5 : 2860 ~ 2866
Barrans SL / 2002 / Germinal center phenotype and bcl-2 expression combined with the International Prognostic Index improves patient risk stratification in diffuse large B-c
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