지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제6호
- 발행연도
- 2011.1
- 수록면
- 665 - 669 (5page)
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Recently we experienced three cases of human epidermal growth factor receptor 2 (HER2)-amplified invasive breast carcinomas associated with co-amplification or gain of chromosome 17 centromere (CEP17) in silver-enhanced in situ hybridization (SISH) analysis. These cases revealed 2+ or 3+ staining for HER2 immunohistochemistry and >6 HER2 copies per cell on SISH analyses. However, the calculated HER2/CEP17 ratios were low (<2.2) and did not fit within the HER2-positive category. We interpreted those cases as HER2-positive tumors based on the number of HER2 copies per cell. There is a potential for misinterpretation of SISH analysis in cases showing increased CEP17 copy number, based on the criterion used for HER2 positivity (HER2 copies >6 per cell vs HER2/CEP17 ratio>2.2). We recommend reporting raw SISH or fluorescence in situ hybridization data, including number of cells counted, average numbers of HER2 and CEP17 signals, and the calculated HER2/CEP17 ratio to prevent underreporting of HER2 amplification.
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참고문헌 (15)
참고문헌 신청
Baehner FL / 2010 / Human epidermal growth factor receptor 2 assessment in a case-control study: comparison of fluorescence in situ hybridization and quantitative reverse tra
Barberis M / 2008 / Quantitative PCR and HER2 testing in breast cancer: a technical and cost-effectiveness analysis / Am J Clin Pathol 129 : 563 ~ 570
Dal Lago L / 2006 / Correction for chromosome-17 is critical for the determination of true Her-2/neu gene amplification status in breast cancer / Mol Cancer Ther 5 : 2572 ~ 2
De P / 2010 / Human epidermal growth factor receptor 2 testing: where are we / J Clin Oncol 28 : 4289 ~ 4292
Harris L / 2007 / American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer / J Clin Oncol 25 : 5287 ~ 5312
Barberis M / 2008 / Quantitative PCR and HER2 testing in breast cancer: a technical and cost-effectiveness analysis / Am J Clin Pathol 129 : 563 ~ 570
Dal Lago L / 2006 / Correction for chromosome-17 is critical for the determination of true Her-2/neu gene amplification status in breast cancer / Mol Cancer Ther 5 : 2572 ~ 2
De P / 2010 / Human epidermal growth factor receptor 2 testing: where are we / J Clin Oncol 28 : 4289 ~ 4292
Harris L / 2007 / American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer / J Clin Oncol 25 : 5287 ~ 5312
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