지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제26권 제11호
- 발행연도
- 2013.1
- 수록면
- 432 - 438 (7page)
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초록· 키워드
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The present study was designed to investigate the expression of p53, Heat Shock Protein 70 (HSP70), and Topoisomerase (Topo) IIα in the preneoplastic lesions and
carcinomas of the gallbladder (GB) and to assess the correlation between the expression of
these proteins and the clinicopathologic parameters by performing immunohistochemistry.
Methods : The immunohistochemical expressions of p53, HSP70 and Topo IIα were evaluated
in 38 gallbladder carcinomas and 3 adenomas. Fifteen CISs and 8 dysplasias that were
located adjacent to invasive carcinomas were also studied. Results : A p53 expression was
identified in 22 (57.9%) of the 38 GB carcinomas, in 9 (64.3%) of 14 CISs, and in none of the
8 dysplasias and 3 adenomas. A HSP70 expression was found in 11 (29%) of the 38 carcinomas,
in 11 (78.6%) of 14 CISs, and in 4 (57.2%) of 7 dysplasias. A Topo IIα expression was
present in 36 (94.7%) of the 38 carcinomas, in 13 (92.9%) of 14 CISs, in 7 (100%) of 7 dysplasias
and in 3 (100%) of 3 adenomas. p53 overexpression was related to the T stage of the
primary tumor, while HSP70 and Topo IIα were not related to any of the clinicopathologic parameters.
Conclusion : p53 may be involved in GB carcinogenesis and in the progression of
cancer. p53 may be also helpful for making the differential diagnosis between dysplasia and
CIS. A further large study is needed to better elucidate the roles of HSP70 and Topo IIα in
GB carcinogenesis.
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참고문헌 (30)
참고문헌 신청
/ / Carcinoma of the extra-hepatic bile ducts stage of disease : 1498 ~ 501
/ 1980 / Type II DNA topoisomerases:enzymesthat can unknot a topologically knotted DNA molecule via a rever-sible double-strand break 19 : 697 ~ 707
/ 1986 / Stress protein systems of mammalian cells 250
/ 1986 / The histogenesis of adenocarcinoma of thegallbladder 58 : 1702 ~ 8
/ 1987 / Immunological evidencefor the association of p53 with a heat shock protein,hsc70,in p53-plus-ras-transformed cell lines 7 : 2863 ~ 9
/ 1980 / Type II DNA topoisomerases:enzymesthat can unknot a topologically knotted DNA molecule via a rever-sible double-strand break 19 : 697 ~ 707
/ 1986 / Stress protein systems of mammalian cells 250
/ 1986 / The histogenesis of adenocarcinoma of thegallbladder 58 : 1702 ~ 8
/ 1987 / Immunological evidencefor the association of p53 with a heat shock protein,hsc70,in p53-plus-ras-transformed cell lines 7 : 2863 ~ 9
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