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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제3호
- 발행연도
- 2017.1
- 수록면
- 306 - 313 (8page)
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초록· 키워드
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Background: Tumor microenvironment has recently drawn attention in that it is related with tumor prognosis. Cancer-associated fibroblast also plays a critical role in cancer invasiveness and progression in colorectal cancers. Periostin (POSTN), originally identified to be expressed in osteoblasts and osteoblast-derived cells, is expressed in cancer-associated fibroblasts in several tissue types of cancer. Recent studies suggest an association between stromal overexpression of POSTN and poor prognosis of cancer patients. Methods: We analyzed colorectal cancer cases for their expression status of POSTN in tumor stroma using immunohistochemistry and correlated the expression status with clinicopathological and molecular features. Results: High level of POSTN expression in tumor stroma was closely associated with tumor location in proximal colon, infiltrative growth pattern, undifferentiated histology, tumor budding, luminal necrosis, and higher TNM stage. High expression status of POSTN in tumor stroma was found to be an independent prognostic parameter implicating poor 5-year cancer-specific survival and 5-year progression-free survival. Conclusions: Our findings suggest that POSTN overexpression in tumor stroma of colorectal cancers could be a possible candidate marker for predicting poor prognosis in patients with colorectal cancers.
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참고문헌 (23)
참고문헌 신청
Bao S / 2004 / Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway / Cancer Cell 5 : 329 ~ 339
Baril P / 2007 / Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway / O
Bozoky B / 2013 / Novel signatures of cancer-associated fibroblasts / Int J Cancer 133 : 286 ~ 293
Chen WJ / 2014 / Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling / Nat Commun 5 : 3472 ~
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136 : E359 ~ E386
Baril P / 2007 / Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway / O
Bozoky B / 2013 / Novel signatures of cancer-associated fibroblasts / Int J Cancer 133 : 286 ~ 293
Chen WJ / 2014 / Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling / Nat Commun 5 : 3472 ~
Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136 : E359 ~ E386
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