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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제49권 제4호
- 발행연도
- 2015.1
- 수록면
- 300 - 309 (10page)
이용수
초록· 키워드
오류제보하기
In this era of precision medicine, our understanding and knowledge of the molecular landscape associated with lung cancer pathogenesis continues to evolve. This information is being increasingly exploited to treat advanced stage lung cancer patients with tailored, targeted therapy. During the management of these patients, minimally invasive procedures to obtain samples for tissue diagnoses are desirable. Cytologic fine-needle aspirates are often utilized for this purpose and are important not only for rendering diagnoses to subtype patients’ lung cancers, but also for ascertaining molecular diagnostic information for treatment purposes. Thus, cytologic fine-needle aspirates must be utilized and triaged judiciously to achieve both objectives. In this review, strategies in utilizing fine-needle aspirates will be discussed in the context of our current understanding of the clinically actionable molecular aberrations underlying non-small cell lung cancer and the molecular assays applied to these samples in order to obtain treatment-relevant molecular diagnostic information.
목차
등록된 정보가 없습니다.
참고문헌 (65)
참고문헌 신청
Bernacki KD / 2012 / Molecular diagnostics of melanoma fine-needle aspirates : a cytology-histology correlation study / Am J Clin Pathol 138:670~677
Killian JK / 2010 / Archival fine-needle aspiration cytopathology(FNAC)samples : untapped resource for clinical molecular profiling / J Mol Diagn 12:739~745
Dejmek A / 2013 / Preparation of DNA from cytological material: effects of fixation, staining, and mounting medium on DNA yield and quality / Cancer Cytopathol 121:344~353
Billah S / 2011 / EGFR and KRAS mutations in lung carcinoma : molecular testing by using cytology specimens / Cancer Cytopathol 119:111~117
Boldrini L / 2007 / Mutational analysis in cytological specimens of advanced lung adenocarcinoma : a sensitive method for molecular diagnosis / J Thorac Oncol 2:1086~1090
Killian JK / 2010 / Archival fine-needle aspiration cytopathology(FNAC)samples : untapped resource for clinical molecular profiling / J Mol Diagn 12:739~745
Dejmek A / 2013 / Preparation of DNA from cytological material: effects of fixation, staining, and mounting medium on DNA yield and quality / Cancer Cytopathol 121:344~353
Billah S / 2011 / EGFR and KRAS mutations in lung carcinoma : molecular testing by using cytology specimens / Cancer Cytopathol 119:111~117
Boldrini L / 2007 / Mutational analysis in cytological specimens of advanced lung adenocarcinoma : a sensitive method for molecular diagnosis / J Thorac Oncol 2:1086~1090
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