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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제4호
- 발행연도
- 2011.1
- 수록면
- 397 - 405 (9page)
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초록· 키워드
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Background: The expression of the inhibitor of apoptosis proteins (IAPs) family has not been fully investigated in colorectal carcinomas. This study investigated IAP expression in colorectal carcinomas and assessed their prognostic significance. Methods: Livin, XIAP, and SMAC/DIABLO expression was assessed by immunohistochemistry in 159 colorectal carcinomas. Correlations between protein expression and clinicopathological features were evaluated. The survival data analysis was estimated according to the Kaplan-Meier method. Results: Increased expression of IAPs in cancer tissues compared to surrounding nonneoplastic counterparts was observed in 67 cases (42.1%) for Livin, 50 cases (31.4%) for XIAP, and 68 cases (42.8%) for SMAC. A significant correlation was found between Livin expression and tumor differentiation, and SMAC expression and tumor location. The recurrence-free and overall survival of patients with low Livin expression were inferior to those of patients with high Livin expression (p=0.054 and 0.095, respectively). High XIAP expression was significantly associated with shorter progression-free survival (p= 0.041). Conclusions: Our study demonstrated that altered expression of IAP family members, including Livin, XIAP, and SMAC, is frequent in colorectal carcinoma. This result suggests that high Livin expression and low XIAP expression may be a favorable prognostic implication related to patient survival.
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참고문헌 (26)
참고문헌 신청
Abd-Elrahman I / 2009 / The inhibitor of apoptosis protein Livin (ML-IAP) plays a dual role in tumorigenicity / Cancer Res 69 : 5475 ~ 5480
Ashhab Y / 2001 / Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern / FEBS Lett 495 : 56 ~ 60
Augello C / 2009 / Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma / BMC Cancer 9 : 125 ~
Choi J / 2007 / Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia / BLOOD 109 : 471 ~ 477
Crnkovi?-Mertens I / 2006 / The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells / Lung Cancer 54 : 135
Ashhab Y / 2001 / Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern / FEBS Lett 495 : 56 ~ 60
Augello C / 2009 / Inhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinoma / BMC Cancer 9 : 125 ~
Choi J / 2007 / Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia / BLOOD 109 : 471 ~ 477
Crnkovi?-Mertens I / 2006 / The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells / Lung Cancer 54 : 135
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