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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제2호
- 발행연도
- 2011.1
- 수록면
- 170 - 174 (5page)
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Background: Making the distinction between large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) is difficult in some samples of biopsy tissues, but we have to separate LCNEC from SCLC because the two types of cancer may need different therapy and they have different prognostic implications. Thus far, there are no specific immunohistochemical markers that allow distinguishing these two kinds of tumors. Methods: We performed an immunohistochemical analysis to study the expressions of p63, Bcl-2, and 34βE12 and to investigate whether these 3 molecules have correlations in LCNEC and SCLC. We also evaluated the expression of the neuroendocrine markers chromogranin, synaptophysin and CD56. Results: A statistical analysis was performed for p63, Bcl-2, and 34βE12 in separate and combined panels. According to the combinations of p63, Bcl-2, and 34βE12, there were frequent expressions of p63-/Bcl-2+ or Bcl-2+/34βE12- in the SCLC, and there was a superior proportion of them in the SCLC rather than that in the LCNEC. The p63-/Bcl-2+ and Bcl-2+/34βE12- antibody combinations showed higher specificities compared to any single antibody for diagnosing SCLC. Conclusions: Bcl-2 and selective p63 or 34βE12 made up a most useful panel of markers for making the differential diagnosis of LCNEC and SCLC.
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참고문헌 (16)
참고문헌 신청
Asamura H / 2006 / Neuroendocrine neoplasms of the lung: a prognostic spectrum / J Clin Oncol 24 : 70 ~ 76
Au NH / 2004 / P63 expression in lung carcinoma: a tissue microarray study of 408 cases / Appl Immunohistochem Mol Morphol 12 : 240 ~ 247
Hiroshima K / 2006 / Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis
Lyda MH / 2000 / Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas / Hum Pathol 31 : 980 ~ 987
Massion PP / 2003 / Significance of p63 amplification and overexpression in lung cancer development and prognosis / Cancer Res 63 : 7113 ~ 7121
Au NH / 2004 / P63 expression in lung carcinoma: a tissue microarray study of 408 cases / Appl Immunohistochem Mol Morphol 12 : 240 ~ 247
Hiroshima K / 2006 / Distinction of pulmonary large cell neuroendocrine carcinoma from small cell lung carcinoma: a morphological, immunohistochemical, and molecular analysis
Lyda MH / 2000 / Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas / Hum Pathol 31 : 980 ~ 987
Massion PP / 2003 / Significance of p63 amplification and overexpression in lung cancer development and prognosis / Cancer Res 63 : 7113 ~ 7121
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