지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제45권 제2호
- 발행연도
- 2011.1
- 수록면
- 188 - 195 (8page)
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초록· 키워드
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Background: Recently, liquid-based cytology (LBC) has been introduced as an alternative to the conventional smear (CS) technique in thyroid fine needle aspiration, due to its diagnostic convenience. Methods: We assessed 77 cases of thyroid fine needle aspiration using the SurePathTM method (SP) as LBC and CS via split-sample techniques. BRAF mutation tests were carried out via polymerase chain reaction and pyrosequencing immediately after diagnosis or a delay of more than one year. Results: In a comparison between SP and CS, the rate of concordance between SP and CS was as high as 84.4% (kappa value, 0.754). In comparison with histologic diagnosis, the overall sensitivity was 100% for both. The specificity was 62.5% for SP and 56.3% for CS. Relative to CS, papillary carcinomas on SP slides revealed more accentuated nuclear irregularities, nucleoli, and reduced nuclear size. In contrast to CS, the delayed BRAFV600E mutation test using SP slides after 1-2 years failed. The use of new primers amplifying shorter product size could help the delayed test achieve success. Conclusions: Differences in the diagnostic efficacy of SP and CS were negligible. The failure of the delayed BRAF mutation test on the SP slides might be associated with DNA degradation.
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참고문헌 (21)
참고문헌 신청
Afify AM / 2001 / Cytologic artifacts and pitfalls of thyroid fine-needle aspiration using ThinPrep: a comparative retrospective review / Cancer 93 : 179 ~ 186
Cheung CC / 2001 / Analysis of ret/PTC gene rearrangements refines the fine needle aspiration diagnosis of thyroid cancer / J Clin Endocrinol Metab 86 : 2187 ~ 2190
Chung KW / 2006 / Detection of BRAFV600E mutation on fine needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAF600E mutation-pre
Cochand-Priollet B / 2003 / Thyroid fine needle aspiration: the morphological features on ThinPrep slide preparations. Eighty cases with histological control / Cytopathology
Crippa S / 2010 / The Bethesda System for reporting thyroid fine-needle aspiration specimens / Am J Clin Pathol 134 : 343 ~ 344
Cheung CC / 2001 / Analysis of ret/PTC gene rearrangements refines the fine needle aspiration diagnosis of thyroid cancer / J Clin Endocrinol Metab 86 : 2187 ~ 2190
Chung KW / 2006 / Detection of BRAFV600E mutation on fine needle aspiration specimens of thyroid nodule refines cyto-pathology diagnosis, especially in BRAF600E mutation-pre
Cochand-Priollet B / 2003 / Thyroid fine needle aspiration: the morphological features on ThinPrep slide preparations. Eighty cases with histological control / Cytopathology
Crippa S / 2010 / The Bethesda System for reporting thyroid fine-needle aspiration specimens / Am J Clin Pathol 134 : 343 ~ 344
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