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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제47권 제4호
- 발행연도
- 2013.1
- 수록면
- 340 - 347 (8page)
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Background: The aim of this study was to examine the expression of CD10 and CD15 in tumor cells, stromal cells and infiltrating inflammatory cells during colorectal carcinoma (CRC) development and to investigate their expression levels between the tumor center and invasive front and compare them to clinicopathological parameters in invasive CRC. Methods: We performed immunohistochemical staining for CD10, CD15, and E-cadherin in 42 cases of CRC, 49 of tubular adenoma, 15 of hyperplastic polyp, and 17 of non-neoplastic colon. Results: CD10 was expressed in tumor cells (tCD10), stromal cells (sCD10) and infiltrating inflammatory cells (iCD10), and CD15 was expressed in tumor cells (tCD15) and infiltrating inflammatory cells (iCD15). Their expressions were progressively increased during CRC development and the iCD10 expression level was significantly correlated with the iCD15 expression level in invasive CRC. Invasive front revealed a higher expression level of iCD10 and iCD15 than the tumor center. Moreover, the iCD15 expression level of invasive front was significantly correlated with the degree of tumor budding and tCD15 in whole tissue sections was closely associated with tumor depth. Conclusions: The present study suggests that the expression of CD10 and CD15 is associated with the development and progression of CRC.
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참고문헌 (28)
참고문헌 신청
Mantovani A / 2011 / Neutrophils in the activation and regulation of innate and adaptive immunity / Nat Rev Immunol 11:519~531
Ardi VC / 2007 / Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis / Proc Natl Acad Sci U S A 104:20262~20267
Queen MM / 2005 / Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression / Cancer Res 65:8896~8904
Dumitru CA / 2012 / Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology / Cancer Immunol Immunother 61:1155~1167
Nakamori S / 1993 / Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study / Cancer Res 53:3632~3637
Ardi VC / 2007 / Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis / Proc Natl Acad Sci U S A 104:20262~20267
Queen MM / 2005 / Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression / Cancer Res 65:8896~8904
Dumitru CA / 2012 / Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology / Cancer Immunol Immunother 61:1155~1167
Nakamori S / 1993 / Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study / Cancer Res 53:3632~3637
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