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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제43권 제4호
- 발행연도
- 2009.1
- 수록면
- 368 - 373 (6page)
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We report two patients with metastatic gastrointestinal stromal tumors (GISTs) with a focus on the morphological features related to Gleevec treatment. In case 1, a 50-year-old woman presented with a 1.8 ㎝ metastatic GIST in the liver after resection of a gastric GIST. Majority of the metastatic tumor showed fibrosis and hyalinization after 8 weeks of Gleevec treatment. CD117-positive cells were present in approximately 1% of the overall tumor. In case 2,
a 2 ㎝ and 14 ㎝ metastatic liver masses were found in a 54-year-old man who had a rectal GIST. After 4 weeks of Gleevec treatment, metastatic tumors showed a decrease in size on CT scan. The metastatic tumors showed a decrease in number of tumor cells. The hemorrhage, cystic changes, necrosis, and fibrosis made up approximately 90% of the tumor. The
morphological features related to Gleevec treatment are important for correct diagnosis and evaluation of tumor response and prognosis.
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등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Antonescu CR / 2008 / Targeted therapy of cancer: new roles for pathologists in identifying GISTs and other sarcomas / Mod Pathol 21 : S31 ~ S36
Bechtold RE / 2003 / Cystic changes in hepatic and peritoneal metastases from gastrointestinal stromal tumors treated with Gleevec / Abdom Imaging 28 : 808 ~ 814
Chen MY / 2002 / Cystic changes in hepatic metastases from gastrointestinal stromal tumors (GISTs) treated with Gleevec (imatinib mesylate) / AJR Am J Roentgenol 179 : 1059 ~
Colecchia M / 2003 / Images in pathology. Morphologic features of response to Gleevec (Imatinib) treatment of GIST / Int J Surg Pathol 11 : 119 ~
Dematteo RP / 2002 / Clinical management of gastrointestinal stromal tumors: before and after STI-571 / Hum Pathol 33 : 466 ~ 477
Bechtold RE / 2003 / Cystic changes in hepatic and peritoneal metastases from gastrointestinal stromal tumors treated with Gleevec / Abdom Imaging 28 : 808 ~ 814
Chen MY / 2002 / Cystic changes in hepatic metastases from gastrointestinal stromal tumors (GISTs) treated with Gleevec (imatinib mesylate) / AJR Am J Roentgenol 179 : 1059 ~
Colecchia M / 2003 / Images in pathology. Morphologic features of response to Gleevec (Imatinib) treatment of GIST / Int J Surg Pathol 11 : 119 ~
Dematteo RP / 2002 / Clinical management of gastrointestinal stromal tumors: before and after STI-571 / Hum Pathol 33 : 466 ~ 477
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