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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제41권 제4호
- 발행연도
- 2007.1
- 수록면
- 238 - 243 (6page)
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초록· 키워드
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Background : The aim of this study was to examine the survivin expression pattern in benign
lesions, atypical ductal hyperplasias (ADH), ductal carcinomas in situ (DCIS) and in invasive
carcinomas of the breast and to evaluate the effect of expression of this marker on the
malignant progression of breast cancers. In addition, the relationship between the expression
of the marker and the clinicopathological characteristics for invasive carcinomas were investigated.
Methods : Immunohistochemical staining using a tissue microarray method for survivin
was performed for 103 benign lesions, 30 ADHs, 26 DCISs and 116 invasive carcinomas.
Results : The expression of cytoplasmic survivin was higher for invasive carcinomas
than for ADHs and DCISs (p<0.05). For breast invasive carcinomas, expression of cytoplasmic
survivin significantly correlated with tumor size, lymph node metastasis and stage (p<0.05).
Conclusions : These results suggest that overexpression of cytoplasmic survivin may be
involved in the development of the late stage of breast malignancy, especially invasiveness.
In breast invasive carcinomas, expression of survivin may be a useful indicator for the evaluation
of patient prognosis.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
/ / DNA damage can induce apoptosis in proliferation lymphoid cells via p53-independent mechanisms inhibitable by Bcl- : 329 ~ 39
/ / Ellis IO. Pathological prognostic factors in breast cancer.I. The value of histological grade in breast cancer experiencefrom a large study with long-term follow-up. His
/ / SommersSC. The pathology of invasive breast cancer. A Syllabus derivedfrom findings of the National Surgical Adjuvant Breast Project protocol (4) : 1 ~ 85
/ 1997 / A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma 3 : 917 ~ 921
/ 1997 / Induction of BCL2 family member MCL1 as early response to DNA damage 14 : 1031 ~ 1039
/ / Ellis IO. Pathological prognostic factors in breast cancer.I. The value of histological grade in breast cancer experiencefrom a large study with long-term follow-up. His
/ / SommersSC. The pathology of invasive breast cancer. A Syllabus derivedfrom findings of the National Surgical Adjuvant Breast Project protocol (4) : 1 ~ 85
/ 1997 / A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma 3 : 917 ~ 921
/ 1997 / Induction of BCL2 family member MCL1 as early response to DNA damage 14 : 1031 ~ 1039
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