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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Recently, studies on mitochondrial DNA (mtDNA) have increased rapidly.
Conventional parameters, such as diversity index, pairwise comparison, are used tointerpret and validate data on autosomal DNA; however, the use of these parametersto validate data from mitochondrial DNA databases (mtDNA DBs) needs to be verifiedbecause of the different transmission patterns of mtDNA. This study was done to verifythe use of these conventional parameters and to test the“ coverage concept”for anew parameter. The mtDNA DB is not very big; however, it is necessary to check howthe change in parameters corresponds to the DB size. For this, we artificiallyrearranged a Korean DB into several small sub-DBs of variable sizes. The resultsshow that the diversity in nucleotide variations and the different haplotype numbers donot vary as the size of DB increases. However, the “coverage”changed a lot. Thecoverage increased from 0.113 in a DB of 100 people to 0.260 in a DB of 653 people.
Additionally, using the“ coverage concept”, we predicted how the total number of haplotypeschanged with variations in the sub-DB size and compared the predicted resultwith final result. In conclusion,“ coverage”, in addition to conventional statistical parameters,can be used to check the usability of an mtDNA DB. Finally, we tried to predictthe size of the whole mtDNA number in Korea using“ saturation concept”.
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참고문헌 (13)
참고문헌 신청
Bunge J / 1993 / Estimating the number of species : a review / JASA 88 : 364 ~ 373
Chao A / 1992 / Estimating the number of classes via sample coverage / JASA 87 : 210 ~ 217
Egeland T / 2004 / Inferring the most likely geographical origin of mtDNA sequence profiles / Ann Hum Genet 68 : 461 ~ 471
Egeland T / 2008 / Estimating haplotype frequency and coverage of databases / PLoS one 3 : e3998 ~
Haas PJ / 2004 / A bi-level Bernoulli scheme for database sampling / In proceedings of the 2004 ACM SIGMOD international conference on Management of data : 275 ~ 286
Chao A / 1992 / Estimating the number of classes via sample coverage / JASA 87 : 210 ~ 217
Egeland T / 2004 / Inferring the most likely geographical origin of mtDNA sequence profiles / Ann Hum Genet 68 : 461 ~ 471
Egeland T / 2008 / Estimating haplotype frequency and coverage of databases / PLoS one 3 : e3998 ~
Haas PJ / 2004 / A bi-level Bernoulli scheme for database sampling / In proceedings of the 2004 ACM SIGMOD international conference on Management of data : 275 ~ 286
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