지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Classical Hodgkin lymphoma (cHL) is a highly curable disease, but the prognosis for relapsed/refractory cHL is grave.
Pembrolizumab has recently shown impressive effects in patients with relapsed/refractory cHL in a phase Ib study (KEYNOTE-013). This report presents a case of a 17-year-old male with refractory cHL who received multiple chemotherapy regimens and radiotherapies, including brentuximab vedotin. Following both the second and fourth cycles of intravenous pembrolizumab 100 mg (2 mg/kg), positron emission tomography/computed tomography (PET/CT) scan showed progression.
However, because performance status and fever improved, treatment was continued, and complete remission was confirmed by PET/CT after eight cycles of pembrolizumab. This case suggests that clinicians need to be aware of the potential for pseudoprogression in patients treated with pembrolizumab.
목차
등록된 정보가 없습니다.
참고문헌 (7)
참고문헌 신청
Armand P / 2016 / Programmed death-1 blockade with pembrolizumab in patients with classical hodgkin lymphoma after brentuximab vedotin failure / J Clin Oncol
Chan TS / 2017 / Low-dose pembrolizumab for relapsed/refractory hodgkin lymphoma: high efficacy with minimal toxicity / Ann Hematol 96 : 647 ~ 651
Di Giacomo AM / 2009 / Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments:
Hodi FS / 2016 / Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with pembrolizumab / J Clin Oncol 34 : 1510 ~ 1517
Horwitz SM / 2016 / NCCN guidelines insights: non-hodgkin's lymphomas, version 3.2016 / J Natl Compr Canc Netw 14 : 1067 ~ 1079
Chan TS / 2017 / Low-dose pembrolizumab for relapsed/refractory hodgkin lymphoma: high efficacy with minimal toxicity / Ann Hematol 96 : 647 ~ 651
Di Giacomo AM / 2009 / Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments:
Hodi FS / 2016 / Evaluation of immune-related response criteria and RECIST v1.1 in patients with advanced melanoma treated with pembrolizumab / J Clin Oncol 34 : 1510 ~ 1517
Horwitz SM / 2016 / NCCN guidelines insights: non-hodgkin's lymphomas, version 3.2016 / J Natl Compr Canc Netw 14 : 1067 ~ 1079
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