지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Pure red cell aplasia (PRCA) in adults is usually idiopathic, although some underlying conditions can cause PRCA.
Immunosuppressive therapy (IST) is used to treat PRCA, but IST has side effects and may fail. The anti-CD52 monoclonal antibody alemtuzumab (ALM) was recently used to successfully treat therapy-resistant PRCA. We herein report successful treatment of secondary PRCA after erythropoietin therapy using ALM and cyclosporin A (CsA) in one patient. The total dose of ALM was 60 mg over 3 days (10, 20, and 30 mg, respectively) plus CsA for at least 6 months. The patient achieved a complete response 18 months after ALM-CsA treatment and his treatment could be changed to a different erythropoietin-stimulating agent.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Au WY / 2005 / Alemtuzumab induced complete remission of therapyresistant pure red cell aplasia / Leuk Res 29 : 1213 ~ 1215
Bates D / 2009 / Alemtuzumab / Int MS J 16 : 75 ~ 76
Casadevall N / 2004 / Recommendations on haematological criteria for the diagnosis of epoetin-induced pure red cell aplasia / Eur J Haematol 73 : 389 ~ 396
Kim H / 2009 / A pilot dose-escalating study of alemtuzumab plus cyclosporine for patients with bone marrow failure syndrome / Leuk Res 33 : 222 ~ 231
Macdougall IC / 2004 / Re-challenging patients who developed pure red cell aplasia with epoetin: can it be done? / Nephrol Dial Transplant 19 : 2901 ~ 2905
Bates D / 2009 / Alemtuzumab / Int MS J 16 : 75 ~ 76
Casadevall N / 2004 / Recommendations on haematological criteria for the diagnosis of epoetin-induced pure red cell aplasia / Eur J Haematol 73 : 389 ~ 396
Kim H / 2009 / A pilot dose-escalating study of alemtuzumab plus cyclosporine for patients with bone marrow failure syndrome / Leuk Res 33 : 222 ~ 231
Macdougall IC / 2004 / Re-challenging patients who developed pure red cell aplasia with epoetin: can it be done? / Nephrol Dial Transplant 19 : 2901 ~ 2905
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