지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Rituximab, an anti-CD20 monoclonal antibody, is an effective target agent against the B lymphocytes in B-cell lymphoidmalignancies and various lymphoproliferative diseases. Moreover, the toxicity of rituximab is less severe than that of conventionalcytotoxic agents, which has promoted the widespread application of rituximab in the treatment of B-cell lymphoma. However,depletion of B lymphocytes by rituximab, which leads to secondary hypogammaglobulinemia, can cause deterioration of humoralimmunity. Although immune reconstitution after hematopoietic stem cell transplantation is known to prevent prolongedhypogammaglobulinemia, very few cases of long-standing hypogammaglobulinemia have been reported. We report herein a caseof prolonged hypogammaglobulinemia after rituximab-containing chemotherapy and splenectomy in a patient with non-Hodgkin’slymphoma and discuss the clinical significance and pathogenetic mechanism of this phenomenon with a literature review.
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참고문헌 (10)
참고문헌 신청
Abulayha AM / 2010 / Depletion of peripheral blood B cells with Rituximab and phenotype characterization of the recovering population in a patient with follicular lymphoma /
Anolik JH / 2007 / B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny / Clin Immunol 122 : 139 ~ 145
Avanzini MA / 2005 / B lymphocyte reconstitution after hematopoietic stem cell transplantation: functional immaturity and slow recovery of memory CD27+ B cells / Exp Hematol
Capolunghi F / 2013 / Why do we need IgM memory B cells / Immunol Lett 152 : 114 ~ 120
Casulo C / 2013 / Incidence of hypogammaglobulinemia in patients receiving rituximab and the use of intravenous immunoglobulin for recurrent infections / Clin Lymphoma Myelo
Anolik JH / 2007 / B cell reconstitution after rituximab treatment of lymphoma recapitulates B cell ontogeny / Clin Immunol 122 : 139 ~ 145
Avanzini MA / 2005 / B lymphocyte reconstitution after hematopoietic stem cell transplantation: functional immaturity and slow recovery of memory CD27+ B cells / Exp Hematol
Capolunghi F / 2013 / Why do we need IgM memory B cells / Immunol Lett 152 : 114 ~ 120
Casulo C / 2013 / Incidence of hypogammaglobulinemia in patients receiving rituximab and the use of intravenous immunoglobulin for recurrent infections / Clin Lymphoma Myelo
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