지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background/Aims: Despite several reports on clinical aspects of anemia and malignancy, little is known of male patients withiron-deficiency anemia (IDA) and malignancy in Korea. We examined the cause of anemia, prevalence of and factors associatedwith malignancy, and treatment response to iron therapy in male IDA patients.
Methods: The results of 202 males with IDA seen from March 2008 to June 2013 were analyzed retrospectively. The patients weredivided into two groups based on the causes of anemia: the cancer group included patients with anemia caused by malignancy andthe non-cancer group included patients with anemia due to other causes. We compared the clinical characteristics and response toiron therapy between the two groups.
Results: The most common cause of IDA was bleeding (42.6%). The prevalence of malignancy was 11.9%, with colorectal cancer(58.3%) being the most common. Among the cancer patients (n = 24), 22 patients (91.7%) were age 50 or older. Independent factorsassociated with malignancy were old age (OR, 1.05; p = 0.026) and a positive stool occult blood test (OR, 7.48; p = 0.001). Thetreatment response to iron therapy based on a normalized hemoglobin level was lower in the cancer group (OR, 0.49; p = 0.31), butthe difference did not reach statistical significance. The treatment response based on the mean hemoglobin level was significantlylower in the cancer group (12.6 ± 2.2 vs. 13.8 ± 1.6 g/dL, p = 0.016).
Conclusions: Old age and a positive stool occult blood test were independent risk factors for malignancy in male IDA patients. Werecommend screening for malignancy in patients older than 50 years or with a positive stool occult blood test.
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참고문헌 (24)
참고문헌 신청
Aapro M / 2012 / Prevalence and management of cancer-related anaemia, iron deficiency and the specific role of i.v. iron / Ann Oncol 23 : 1954 ~ 1962
Astin M / 2011 / The diagnostic value of symptoms for colorectal cancer in primary care: a systematic review / Br J Gen Pract 61 : e231 ~ 243
Bermejo F / 2009 / A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases / World J Gastroenterol 15 : 4638 ~ 4643
Bini EJ / 1999 / Is upper gastrointestinal endoscopy indicated in asymptomatic patients with a positive fecal occult blood test and negative colonoscopy / Am J Med 106 : 613
Bretthauer M / 2011 / Colorectal cancer screening / J Intern Med 270 : 87 ~ 98
Astin M / 2011 / The diagnostic value of symptoms for colorectal cancer in primary care: a systematic review / Br J Gen Pract 61 : e231 ~ 243
Bermejo F / 2009 / A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases / World J Gastroenterol 15 : 4638 ~ 4643
Bini EJ / 1999 / Is upper gastrointestinal endoscopy indicated in asymptomatic patients with a positive fecal occult blood test and negative colonoscopy / Am J Med 106 : 613
Bretthauer M / 2011 / Colorectal cancer screening / J Intern Med 270 : 87 ~ 98
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