지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Membranous glomerulonephritis is one of the most common causes of nephrotic syndrome in adults. Pulmonary alveolarproteinosis (PAP) is a rare lung disease in which abnormal accumulation of surfactant occurs within the alveoli. We describe a61-year-old man with concurrent membranous glomerulonephritis and PAP, which is very rare; both are pathophysiologicallyrelated to an abnormal immune response. A patient came to hospital with leg edema but no respiratory symptoms. Chest X-ray andCT showed classical PAP findings, which are ground-glass opacities with interlobular septal thickening, in both lung fields. Abubbly whitish secretion retrieved via broncho-alveolar lavage showed neutrophils and lymphocytes as well as Periodicacid-Schiff-positive proteinaceous materials. A kidney biopsy revealed findings of membranous glomerulonephritis with irregularsubepithelial deposits by electron microscopy. At 1 year after diagnosis, the membranous glomerulonephritis was well undercontrol with steroids and mycophenolate mofetil but PAP became aggravated gradually and whole-lung lavage was needed.
목차
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참고문헌 (7)
참고문헌 신청
Beck LH Jr / 2009 / M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy / N Engl J Med 361 : 11 ~ 21
Kitamura T / 1999 / Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor / J
Nogee LM / 1993 / Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis / N Engl J Med 328 : 406 ~ 410
Ronco P / 2010 / Antigen identification in membranous nephropathy moves toward targeted monitoring and new therapy / J Am Soc Nephrol 21 : 564 ~ 569
Seymour JF / 2002 / Pulmonary alveolar proteinosis: progress in the first 44 years / Am J Respir Crit Care Med 166 : 215 ~ 235
Kitamura T / 1999 / Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor / J
Nogee LM / 1993 / Brief report: deficiency of pulmonary surfactant protein B in congenital alveolar proteinosis / N Engl J Med 328 : 406 ~ 410
Ronco P / 2010 / Antigen identification in membranous nephropathy moves toward targeted monitoring and new therapy / J Am Soc Nephrol 21 : 564 ~ 569
Seymour JF / 2002 / Pulmonary alveolar proteinosis: progress in the first 44 years / Am J Respir Crit Care Med 166 : 215 ~ 235
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