지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Adult onset Still’s disease (AOSD) is a systemic autoinflammatory disorder that presents with recurrent fever, extreme fatigue,and joint pain. Pulmonary involvement is not uncommon and, although rare, severe pneumonitis can progress to respiratory failure.
Still’s disease-associated pneumonitis is generally treated with immunosuppressive agents, but improvement in our understandingof systemic inflammatory processes led us to explore alternative agents. Anakinra is an interleukin-1 receptor antagonist used totreat autoinflammatory disorders resistant to immunosuppressive therapy. Several case reports have demonstrated efficacy ofanakinra in treating AOSD, but its relevance in cases complicated with severe pneumonitis has not been examined. Our patient’sdisease activity was not controlled with systemic steroids and cyclophosphamide. Treatment with anakinra led to a dramatic clinicalresponse. This is the first reported case of AOSD with severe pneumonitis refractory to conventional therapy successfully treatedwith anakinra.
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참고문헌 (10)
참고문헌 신청
Cheema GS / 1999 / Pulmonary involvement in adult-onset Still's disease / Curr Opin Pulm Med 5 : 305 ~ 309
Church LD / 2008 / Primer: inflammasomes and interleukin 1beta in inflammatory disorders / Nat Clin Pract Rheumatol 4 : 34 ~ 42
Franchini S / 2010 / Efficacy of traditional and biologic agents in different clinical phenotypes of adult-onset Still's disease / Arthritis Rheum 62 : 2530 ~ 2535
Kontzias A / 2012 / The use of Canakinumab, a novel IL-1β long-acting inhibitor, in refractory adult-onset Still's disease / Semin Arthritis Rheum 42 : 201 ~ 205
Kraetsch HG / 2001 / Successful treatment of a small cohort of patients with adult onset of Still's disease with infliximab: first experiences / Ann Rheum Dis 60 (3) : iii55
Church LD / 2008 / Primer: inflammasomes and interleukin 1beta in inflammatory disorders / Nat Clin Pract Rheumatol 4 : 34 ~ 42
Franchini S / 2010 / Efficacy of traditional and biologic agents in different clinical phenotypes of adult-onset Still's disease / Arthritis Rheum 62 : 2530 ~ 2535
Kontzias A / 2012 / The use of Canakinumab, a novel IL-1β long-acting inhibitor, in refractory adult-onset Still's disease / Semin Arthritis Rheum 42 : 201 ~ 205
Kraetsch HG / 2001 / Successful treatment of a small cohort of patients with adult onset of Still's disease with infliximab: first experiences / Ann Rheum Dis 60 (3) : iii55
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