지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Ventilator-induced lung injury (VILI) is the additional inflammatory damage caused by mechanical ventilation, especially inacute respiratory distress syndrome (ARDS). VILI can induce a systematic inflammatory response, resulting in multiple organdysfunction syndrome, which is the major cause of death in ARDS patients. The two main mechanisms of VILI are physical stretchinjury caused by a high tidal volume and shearing force caused by the reopening and collapse of alveoli in atelectatic lung.
Protective ventilation strategies to prevent VILI include low tidal volume ventilation, high positive end-expiratory pressure, proneposition ventilation, the alveolar recruitment maneuver, and extracorporeal membrane oxygenation. The clinical support isstrongest for low tidal volume ventilation, which should be used in all cases of ARDS. However, its effectiveness might be limitedbecause of the severe spatial heterogeneity of the lung involvement, which cannot completely prevent regional alveolar distension.
Although there is insufficient clinical evidence supporting the other strategies, and they are controversial, various strategies otherthan low tidal volume ventilation should be considered in selected clinical conditions in which they might be effective.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
/ 1999 / International consensus conferences in intensive care medicine: Ventilator-associated Lung Injury in ARDS: this official conference report was cosponsored by the Ame
/ 2000 / Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome: the Acute Respira
Amato MB / 1998 / Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome / N Engl J Med 338 : 347 ~ 354
Bartlett RH / 1986 / A prospective study of acute hypoxic respiratory failure / Chest 89 : 684 ~ 689
Brochard L / 1998 / Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome: the Multicenter Trail Group on Tidal Volu
/ 2000 / Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome: the Acute Respira
Amato MB / 1998 / Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome / N Engl J Med 338 : 347 ~ 354
Bartlett RH / 1986 / A prospective study of acute hypoxic respiratory failure / Chest 89 : 684 ~ 689
Brochard L / 1998 / Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome: the Multicenter Trail Group on Tidal Volu
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