지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background/Aims:Although many individual cases of toxic hepatitis have been reported, there are few comprehensive systematic studies and few reports of the pathological findings in toxic hepatitis. We studied the clinical characteristics, pathology, and prognosis of patients with toxic hepatitis.
Methods:A retrospective analysis examined the medical records of 184 cases of toxic hepatitis diagnosed from January 2004 to January 2010. Liver biopsies were performed in 62 of these cases. Patients were included in this study it they had a RUCAM score ≥4.
Results:The incidence was higher in women (n = 125) than in men (n = 59). The mean age of the patients was 45.9 ± 14.4 years. The most common symptom was jaundice (56/184; 30.4%). The causative agents of the disease included herbal medications (43.5%), traditional therapeutic preparations (33.7%), and prescribed medications (21.7%). The pathological findings of toxic hepatitis included necrosis (n = 62), cholestasis (n = 43), steatosis (n = 23), eosinophilic infiltrations (n = 22), and ballooning degeneration (n = 20). The patients with cholestasis and necrosis were hospitalized longer and showed delayed recovery. The only prognostic factor associated with the hospitalization and recovery periods was the serum total bilirubin at the time of admission (p < 0.001).
Conclusions:The common pathological findings of toxic hepatitis were necrosis and cholestasis, although these are not specific to toxic hepatitis. Only the total bilirubin at the time of admission was significantly associated with the duration of hospitalization and recovery. (Korean J Med 2011;81:53-63)
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Benichou C / 1990 / Criteria of drug-induced liver disorders: report of an international consensus meeting / J Hepatol 11 : 272 ~ 276
Bjornsson E / 2006 / Clinical characteristics and prognostic markers in disulfiram-induced liver injury / J Hepatol 44 : 791 ~ 797
Bjornsson E / 2007 / Long-term follow-up of patients with mild to moderate druginduced liver injury / Aliment Pharmacol Ther 26 : 79 ~ 85
Chae HB / 2004 / Clinical features and diagnosis of drug-induced liver injury / Korean J Hepatol 10 (Suppl 1) : S7 ~ S18
De Berardinis V / 2000 / Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes / Mol Pharmacol 58 : 542 ~
Bjornsson E / 2006 / Clinical characteristics and prognostic markers in disulfiram-induced liver injury / J Hepatol 44 : 791 ~ 797
Bjornsson E / 2007 / Long-term follow-up of patients with mild to moderate druginduced liver injury / Aliment Pharmacol Ther 26 : 79 ~ 85
Chae HB / 2004 / Clinical features and diagnosis of drug-induced liver injury / Korean J Hepatol 10 (Suppl 1) : S7 ~ S18
De Berardinis V / 2000 / Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes / Mol Pharmacol 58 : 542 ~
이 논문의 저자 정보
최근 본 자료
댓글(0)
0