지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Thrombocytopenia is a common manifestation of rickettsial disease. However, the pathogenesis of thrombocytopenia in manyrickettsial diseases is poorly understood. Thrombocytopenia may be associated with consumption due to widespread endothelialdamage or disseminated intravascular coagulation, hypersplenism, decreased marrow production, and immune-mediated plateletdestruction. Some reports have found anti-platelet antibodies detected in thrombocytopenic patients with rickettsial disease. Inaddition to thrombocytopenia, facial palsy and Guillain-Barré syndrome were also reported as immune-mediated phenomena inscrub typhus. Here we report a case diagnosed as immune-mediated thrombocytopenia associated with scrub typhus. This is the firstreport of immune thrombocytopenic purpura (ITP) associated with scrub typhus in Korea. The patient exhibited eschar with a hightiter of anti-tsutsugamushi antibody, thrombocytopenia, severe gastrointestinal hemorrhage, and purpura on the lower region ofboth legs. After steroid treatment, the sustained thrombocytopenia recovered.
목차
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참고문헌 (10)
참고문헌 신청
Arraga-Alvarado C / 1999 / Fine structural characterisation of a Rickettsia-like organism in human platelets from patients with symptoms of ehrlichiosis / J Med Microbiol 48
Beardsley DS / 1998 / Platelet autoantibodies in immune thrombocytopenic purpura / Transfus Sci 19 : 237 ~ 244
Grindem CB / 1999 / Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky mountain spotted fever and ehrlichiosis / J Am Anim Hosp Assoc 35 : 56 ~ 61
Kim DM / 2011 / Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi / Diagn Microbiol Infect Dis 69 : 271 ~ 274
Kim SJ / 2000 / The clinical significance of upper gastrointestinal endoscopy in gastrointestinal vasculitis related to scrub typhus / Endoscopy 32 : 950 ~
Beardsley DS / 1998 / Platelet autoantibodies in immune thrombocytopenic purpura / Transfus Sci 19 : 237 ~ 244
Grindem CB / 1999 / Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky mountain spotted fever and ehrlichiosis / J Am Anim Hosp Assoc 35 : 56 ~ 61
Kim DM / 2011 / Scrub typhus meningoencephalitis occurring during doxycycline therapy for Orientia tsutsugamushi / Diagn Microbiol Infect Dis 69 : 271 ~ 274
Kim SJ / 2000 / The clinical significance of upper gastrointestinal endoscopy in gastrointestinal vasculitis related to scrub typhus / Endoscopy 32 : 950 ~
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