지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
In randomized phase 3 clinical trials azacitidine has been shown to prolong survival in patients with higher-risk myelodysplasticsyndrome (MDS). Therefore, azacitidine therapy should be considered for treating MDS patients with higher-risk disease. A 78-year-old male was administered the first cycle of azacitidine treatment for higher-risk MDS. On day three of chemotherapy he complainedof fever and dyspnea, and radiographic findings revealed bilateral perihilar-peribronchial infiltration and a small amount ofpleural effusion. Considering the possibility of pneumonia, intravenous broad-spectrum antibiotics were administered and azacitidinetherapy was discontinued. Upon improvement of the patient’s subjective symptoms and radiographic abnormalities, azacitidinetherapy was resumed. However, fever and dyspnea developed again upon recommencement of azacitidine therapy. A diagnosiswas made of azacitidine-induced lung injury and corticosteroid treatment was administered. Although lung injury is a rare complicationinduced by azacitidine, physicians should be aware of this life-threatening side effect.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Adams CD / 2005 / Azacitidine-induced interstitial and alveolar fibrosis in a patient with myelodysplastic syndrome / Pharmacotherapy 25 : 765 ~ 768
Fenaux P / 2009 / Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label
Hayashi M / 2012 / Azacitidine-induced pneumonitis in a patient with myelodysplastic syndrome: first case report in Japan / Intern Med 51 : 2411 ~ 2415
Hueser CN / 2007 / Azacitidine-associated hyperthermia and interstitial pneumonitis in a patient with myelodysplastic syndrome / Pharmacotherapy 27 : 1759 ~ 1762
Meersseman W / 2009 / Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy study / Intensive Care Med 35 :
Fenaux P / 2009 / Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label
Hayashi M / 2012 / Azacitidine-induced pneumonitis in a patient with myelodysplastic syndrome: first case report in Japan / Intern Med 51 : 2411 ~ 2415
Hueser CN / 2007 / Azacitidine-associated hyperthermia and interstitial pneumonitis in a patient with myelodysplastic syndrome / Pharmacotherapy 27 : 1759 ~ 1762
Meersseman W / 2009 / Significance of the isolation of Candida species from airway samples in critically ill patients: a prospective, autopsy study / Intensive Care Med 35 :
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