지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) are the most widely used medications, based on their antipyretic,analgesic, and anti-inflammatory effects. However, both aspirin and NSAIDs cause hypersensitivity reactions through immunologicas well as non-immunologic mechanisms. Except for the rare single-NSAID-induced reaction, most hypersensitivity reactionsshow cross-reactive features to other NSAIDs regardless of their chemical structure. An accurate correct medical history is the mostimportant diagnostic approach, whereas the roles of blood and skin tests are limited in the majority of cases of NSAIDshypersensitivity. Although able to confirm the presence of a hypersensitivity reaction, an oral or bronchial provocation test shouldbe performed only under the supervision of a skilled physician at a well-equipped institution. Avoidance of the causative NSAIDand all cross-reactive NSAIDs is the cornerstone of management. Patients who require treatment with aspirin or NSAIDs can undergoaspirin desensitization. Genetic predisposition to hypersensitivity to NSAIDs have been demonstrated, but a clear understandingof the pathophysiologic and phenotypic diversity of these hypersensitivity reactions requires further studies, includingfunctional ones.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Asero R / 2003 / Intolerance to nonsteroidal anti-inflammatory drugs might precede by years the onset of chronic urticaria / J Allergy Clin Immunol 111 : 1095 ~ 1098
Burnett T / 2013 / Mechanisms of aspirin desensitization / Immunol Allergy Clin North Am 33 : 223 ~ 236
Erbagci Z / 2004 / Multiple NSAID intolerance in chronic idiopathic urticaria is correlated with delayed, pronounced and prolonged autoreactivity / J Dermatol 31 : 376 ~ 382
Hope AP / 2009 / Rational approach to aspirin dosing during oral challenges and desensitization of patients with aspirin-exacerbated respiratory disease / J Allergy Clin Immu
In KH / 1997 / Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription / J Clin Inve
Burnett T / 2013 / Mechanisms of aspirin desensitization / Immunol Allergy Clin North Am 33 : 223 ~ 236
Erbagci Z / 2004 / Multiple NSAID intolerance in chronic idiopathic urticaria is correlated with delayed, pronounced and prolonged autoreactivity / J Dermatol 31 : 376 ~ 382
Hope AP / 2009 / Rational approach to aspirin dosing during oral challenges and desensitization of patients with aspirin-exacerbated respiratory disease / J Allergy Clin Immu
In KH / 1997 / Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription / J Clin Inve
이 논문의 저자 정보
최근 본 자료
댓글(0)
0