지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Severe adverse cutaneous reactions (SCARs) include Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) anddrug reaction with eosinophilia and systemic symptoms (DRESS). Although recent advances in pharmacogenomics have revealedthe association between specific human leukocyte antigens (HLAs) and certain drug-induced SCARs, such associations were foundin a limited number of drug-associated SCARs and are not sufficient to explain many other drug-related SCARs. After introducingresearch on the HLA-restricted T cell response, the role of the T cell receptor in drug binding was emphasized and a new conceptcalled “pharmacological interactions of drug with immune receptors” has been conceptualized over recent decades. Currently,many international and domestic collaborative consortia have been formed and should enable the phenotypic standardization ofSCARs at the earliest practicable time to provide valuable insights into its pathogenesis and to find an ideal method to prevent patientsfrom developing SCARs.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bastuji-Garin S / 1993 / Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme / Arch Dermatol 129 : 92 ~ 96
Camous X / 2012 / Drug reaction with eosinophilia and systemic symptoms: an update on pathogenesis / Curr Opin Immunol 24 : 730 ~ 735
Chang YS / 2007 / Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management / Cornea 26 : 123 ~ 129
Chen P / 2011 / Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan / N Engl J Med 364 : 1126 ~ 1133
Chung WH / 2004 / Medical genetics: a marker for Stevens-Johnson syndrome / Nature 428 : 486 ~
Camous X / 2012 / Drug reaction with eosinophilia and systemic symptoms: an update on pathogenesis / Curr Opin Immunol 24 : 730 ~ 735
Chang YS / 2007 / Erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: acute ocular manifestations, causes, and management / Cornea 26 : 123 ~ 129
Chen P / 2011 / Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan / N Engl J Med 364 : 1126 ~ 1133
Chung WH / 2004 / Medical genetics: a marker for Stevens-Johnson syndrome / Nature 428 : 486 ~
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